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2.A.1.3.53
Azole resistance protein 1

Accession Number:P50080
Protein Name:Azole resistance protein 1
Length:613
Molecular Weight:67169.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Azole

Cross database links:

Genevestigator: P50080
eggNOG: COG0477
HEGENOM: HOG000247960
DIP: DIP-7543N
Entrez Gene ID: 853139   
Pfam: PF07690   
KEGG: sce:YGR224W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0045118 F:azole transporter activity

References (5)

[1] “Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII.”  van der Aart Q.J.M.et.al.   8701610
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[3] “Expression of the AZR1 gene (ORF YGR224w), encoding a plasma membrane transporter of the major facilitator superfamily, is required for adaptation to acetic acid and resistance to azoles in Saccharomyces cerevisiae.”  Tenreiro S.et.al.   11113970
[4] “A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast.”  Hikkel I.et.al.   12529331
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKGEPKTYSM SDLSYYGEKA QQQNEKQQKQ YVVRRNSTQS TSKQNVSVVL EDNASESNEL 
61:	PKGFILYASL IALALSLFLA ALDIMIVSTI IEEVAKQFGS YSEIGWLFTG YSLPNALLAL 
121:	IWGRIATPIG FKETMLFAIV IFEIGSLISA LANSMSMLIG GRVIAGVGGC GIQSLSFVIG 
181:	STLVEESQRG ILIAVLSCSF AIASVVGPFL GGVFTSSVTW RWCFYVNLPI GGLAFFLFLF 
241:	FYNPGLSTFQ ETMDNIRKFP SQFIEIVRNV AYHLLKIKGF SKLNGWRKPF MELIFMYDII 
301:	EFVFCSAGFT CILLAFTFGG NRYAWNSASI IILFIIGIVL VVLAGIYDFL VFPKFNIVKA 
361:	TPHYQPLMSW TNIKKPGIFT VNIALFLTCA GYISQFTYIV QYFQLIYNDS AWRAAVHLVA 
421:	CIISTVVTAI LCGAITDKTR QIKPIIVISS IFGVVGAGIL TLLNNNANNS AHIGLLILPG 
481:	VAFGGLAQSS MLASQIQLDK KSPTFRSDFV SITTFNTFCK NLGQALGGVI SNTVFSAAAI 
541:	KKLTKANIQL PDGTTVDNLV IYRQTNFDGS HSKLGNIISE SLTDVFYMAL GFYALSLIFA 
601:	VFASNKKVTA SLR