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2.A.1.3.61
MDR efflux pump, MdeA.  Exports quaternary ammonium compounds and antibiotics (Huang et al. 2004). Also exports hoechst 33342, doxorubicin, daunorubicin, tetraphenyl phosphonium, ethidium bromide and rhodamine 6G (Yamada et al. 2006).

Accession Number:Q7A3S4
Protein Name:SA2203 protein
Length:479
Molecular Weight:52169.00
Species:Staphylococcus aureus (strain N315) [158879]
Number of TMSs:14
Substrate Hoechst 3342, doxorubicin, daunorubicin, tetraphenylphosphonium, ethidium bromide, Rhodamine 6G

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSKKQKLTMI ITMLMGGFFG LLNETLLVTA LPSIMKDFEI SYTQVQWLTT AFLLTNGIVI 
61:	PLSALVIQRY TTRQVFLVGI SIFFLGTLLG GLSPHFATLL VARIIQALGA GIMMPLMMTT 
121:	ILDVFQPHER GKYMGIFGLV IGLAPAIGPT LSGYLVEYLN WRSLFHVVAP IAAVTFLIGF 
181:	KTIKNVGTTI KVPIDFISVI FSVLGFGGLL YGTSSISEKG FDNPIVLVSM IGGVVLVALF 
241:	VLRQYRLSTP LLNFAVFKNK QFTVGIIIMG VTMVSMIGSE TILPIFVQNL LHRSALDSGL 
301:	TLLPGAIVMA FMSMTSGALY EKFGPRKLAL VGMAIVVITT AYFVVMDEQT STIMLATVYA 
361:	IRMVGIALGL IPVMTHTMNQ LKPEMNAHGS SMTNTVQQIA GSIGTAALIT ILSHASKNFS 
421:	PTMSDYNGMN KIDMMNQIKV DTMLHGYHAG FLFALLITVV SFFCSFMLQG KKKEVDSRQ