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2.A.1.3.7
Actinorhodin:H+ antiporter, ActVa or ActA (Tahlan et al., 2007)

Accession Number:Q53903
Protein Name:ActVa aka ACTVA1 aka SCO5076 aka SCBAC28G1.02
Length:533
Molecular Weight:54546.00
Species:Streptomyces coelicolor [1902]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Actinorhodin, H+

Cross database links:

HEGENOM: HBG679341
RefSeq: NP_629226.1   
Entrez Gene ID: 1100517   
Pfam: PF07690   
BioCyc: SCOE100226:SCO5076-MONOMER   
KEGG: sco:SCO5076   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Organisation and functions of the actVA region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor.”  Caballero J.L.et.al.   1766437
[2] “Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).”  Bentley S.D.et.al.   12000953

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTANPGRPGG PADQGHPRRW AILGVLVLSL VGIILDNTVL NVTLRTLTDP EQGLGASHSQ 
61:	VEWVLSAYTL AFAATLFTWG VLGDRLGRRR VLLLGLGLFG LSSLAGAYAG SPEQLIAARA 
121:	CMGVSGAAVL PSTLATIAAV FPLRERPKAL GIWAASVGFA LGIGPVTGGI LLAHFWWGSV 
181:	LLVNVPLMAG CLVAVVLVVP ETRGTAGRRV DAAGLLLSIA GVVPLVYAII EAGRSGGVTR 
241:	PAVWAAGLAG LGLLLVFLWH ERRTPEPSLE LGFFRMKAFS TAVAAVGFVS FAMMGFLFFS 
301:	AFYLQSVRGY TPLQAGGCTV ALAVANVVCG PLSTVLVRSI GPRNVCAAGM LAVTASLCGV 
361:	TFVTQHAPVW LILVLFAALG AGVACVMPTA AVSIMNAIPR EKAGVASAMN NTVRQLGGAL 
421:	GVAVLGSLMG AAYRRGIEDE LAVLPPSARH QAGESLDATL LAATRLGESG LVGPARQAFL 
481:	DAMHLAAGAA AAVALVGALA VLRWLPSSVT TPTPPAGAVP GREHSDHLKV QGS