TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.3.70
Probable exporter of aromatic compounds of 559 aas and 16 putative TMSs in an apparent 4 + 4 + 4 + 4 arrangement. May function in aromatic compoound detoxification.  Regulated by a MarR-like transcriptional regulator that is encoded in the same operon. Ten-fold induction occurs in response to aromatic aldehydes such as benzaldehyde (Fiorentino et al. 2007). The same MarR protein controls transcription of a gene encoding an NADH-dependent alcohol dehydrogenase (Sso2536).

Accession Number:Q97YH0
Protein Name:Permease, multidrug efflux
Length:559
Molecular Weight:60491.00
Species:Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [273057]
Number of TMSs:16
Substrate Aromatic compounds

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MQYKWVALSN TTIGVLMASI NGTITLISLP AIFRGININP FTSFQYLLWI LMGYNVVTAT 
61:	LLVSFGRLSD IFGRVRLYNL GFLIFTIGSI LLFLTPNTGS LGALELILFR IIQGIGGAFL 
121:	FANSAAIITD AFPFNERGKA LGINQIAALA GSLVGLILGG ILSVIDWRYI FLVSVPVGIL 
181:	GTIWSYTKLK EISVPSRSEG IDWAGNTTFG LGLILILIAI TYGLLPYGSS QLGWGNPFVI 
241:	GSMVAGIGLI GAFIYIENKV KYPMFRLELF KIRMFTAGNL ASFLRSIAYG GLMIMLIIFL 
301:	QGIWLPLHGY SYEETPFWAG IYTIPLMIGF VTMGPISGWL SDRYGARLLA TLGMVIVGIG 
361:	FLLLTLLPYN FNYPEFALII FIMGLGNGMF ASPNTASIMN SVPPKYRGVA SGMRATIQNT 
421:	GQTLSMALFF TIVIISLAST LPTALANAVT QAGAPQLAPL MQKIPVTGAL FAAFLGYDPV 
481:	KTILSSLPPQ ITVPPQAVAV MEQHDWFPTV IAPSFMIALR EAFYISSVLT FIAAIASALR 
541:	GRRVIAEQQD GGEINAKNR