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2.A.1.3.71
Putative multidrug-resistance exporter of 553 aas and 14 putative TMSs, KNQ1. It is a drug efflux permease for several toxic compounds that in multiple copies confer increased dithiothreitol resistance. KNQ1 does not export dithiothreitol or function in recombinant protein secretion. KNQ1 gene amplification or deletion resulted in enhanced transcription of iron transport genes, suggesting,  a role in iron homeostasis on which dithiothreitol tolerance may depend (Marchi et al. 2007).

Accession Number:Q874B4
Protein Name:Drug efflux permease KNQ1
Length:553
Molecular Weight:60192.00
Species:Kluyveromyces lactis (Yeast) [28985]
Number of TMSs:13
Substrate

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FASTA formatted sequence
1:	MPSEKSVTFP KGSLFHQDTL KHLKFICILI ACGLDLASVG AMIVLVTDIE TRFNVSHTQS 
61:	GWALTSYVIT FAGFIAFFGR VGDIVGNGIM MCVFSVIFGI FSLLCAVVPN FIAFTVFRAF 
121:	QGMAGAGIVP CAYALVNKMF QGPNLQRYFS ILSSVISAMA GVGFIIGGAF GETALGYKSF 
181:	FYFLFAASLA TAAVICVLIG YPELLLNRHS YKEKFQRVYK LDVIGCLLFI SGSILLVVGL 
241:	TQGGESWNDP TAYVPLAVSI VLLIIFFMWN LGYAVVLKLI KPISTHKGYA YMESVNLLIP 
301:	KNLMFSHNFI PVLLATFFLF CGFMVVMYVI ANYSATVEGN SMIVASIKII PMISGLVLAN 
361:	GTVAYKQDLF KPKNALVVGS FISILGGAFF VPIKYVDDNL FWKLFFMGGF FTGLGGAFFF 
421:	CYMITMAIGD APDQYKALAG GIVQTSGQFG NEVSLSIVIS LLGNQTTDKA DLRDRFQNAS 
481:	YIVITAATIS TLVSLFLVKG PLESSGDEEK QLSECSESTT SSNSNPENQI ETVMVICPDT 
541:	RDKKEETVDQ YLA