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2.A.1.3.9
Lincomycin:H+ antiporter

Accession Number:P46104
Protein Name:LmrA
Length:481
Molecular Weight:50421.00
Species:Streptomyces lincolnensis [1915]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Lincomycin, H+

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Molecular cloning and characterization of two lincomycin-resistance genes, lmrA and lmrB, from Streptomyces lincolnensis 78-11.”  Zhang H.Z.et.al.   1328813
[2] “Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.”  Peschke U.et.al.   8577249

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSVFARATSL FSRAARTRAA DEAARSRSRW VTLVFLAVLQ LLIAVDVTVV NIALPAIRDS 
61:	FHVDTRQLTW VVTGYTVVGG GLLMVGGRIA DLFGRRRTLL FGAFLFGASS LAAGLAPNLE 
121:	LLVLARFGQG AGEALSLPAA MSLIACSSRT APFQGVERLA SVASVGLVLG FLLSGVITQL 
181:	FSWRWIFLIN IPLVSLVLVA VLLLVKKDET TARNPVDLPG ALLFTAAPLL LIFGVNELGE 
241:	DEPRLPLAVG SLLAAAVCAA AFVAVERRTA HPLVPLTFFG NRVRLVANGA TVLLSAALST 
301:	SFFLLTMHLQ EERDLSPIEA GLSFLPLGLS LILACVLVRG LIERIGTTGA AVLGMALAGP 
361:	RHRLFALLPS DNSLLTSVFP GMILLLRMAT GLVALQNAAL HAVTEADAGV ASGVQRCADQ 
421:	LGGASGIAVY VSIGFSPHLG GDWDPFTVAY SLAGIGLIAA VLAVLALSPD RRLAAPREQE 
481:	D