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2.A.1.32.1
Putative aromatic compound/drug exporter. Enhances expression of the sigma X gene that functions to modify the cell envelope (Turner and Helmann, 2000). yitG is reported to be a mutator gene that inhibits transition base substitutions (Sasaki and Kurusu, 2004).

Accession Number:O06742
Protein Name:YitG
Length:425
Molecular Weight:45827.00
Species:Bacillus subtilis [1423]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Aromatic drugs

Cross database links:

Pfam: PF07690   
BioCyc: SUBTI:BSU10980-MONOMER   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (1)

[1] “A Bacillus subtilis chromosome segment at the 100 degrees to 102 degrees position encoding 11 membrane proteins.”  Roche B.et.al.   9353932

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	CSEMESSKQN NGMTIVAIGS IPLILTLGNS MLIPILPKMK SELHLSQFQV SLVITVFSLI 
61:	AAFAIPIVGY LADRFSRKVI IIPCLILYGA GGLLAGFAAG FFDNAYPWVM AGRALQGIGA 
121:	AGTGPIAMAL TGDLFKGAQE SKVLGLVEAS NGMGKVLSPI IGSLIALLVW YGAFFAFPVF 
181:	CIISIVLTWI FIKEKKKEKE PPPIGQYAKG LLSVFKHEGR WLFTAYLAGA TCLFTLFGIL 
241:	FYLSDVLEKT YDTDGVKKGL ILAIPLLVMC VTSYTTGSKI GQKQSLMKKL IVLGLAFMTV 
301:	SYAALSFIEN LVLFISVLVL SSIGSGLVLP CVNSFITGAV GKERRGFVTS LYGSVRFLGV 
361:	AIGPPIFGRL MQWSRPGMFL SIAGLTLVVG ILVMMLIHVK QNNEETKEKE DPKMAGNRLQ 
421:	PAEER