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2.A.1.33.1
MFS homologue, YqgE. It is cotranscribed with ftsI, encoding the peptidoglycan transpeptidase that crosslinks peptidoglycan strands, releasing free D-alanine. Possibly YqgE is a D-alanine uptake porter. Its expression causes a decrease in the amount of sigma W synthesis, the sigma factor for genes involved in detoxification and antimicrobial synthesis (Turner and Helmann 2000).

Accession Number:P54487
Protein Name:YqgE
Length:430
Molecular Weight:48260.00
Species:Bacillus subtilis [1423]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate D-alanine

Cross database links:

HEGENOM: HBG314155
RefSeq: NP_390380.2   
Entrez Gene ID: 938196   
Pfam: PF07690   
KEGG: bsu:BSU25010   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport

References (3)

[1] “Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes.”  Mizuno M.et.al.   8969508
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSKLKKVIGD VDVNKGLLFL LTIGGLYSLG IALSNTFVNV YLWKQSGKFI DLAIYNLSIV 
61:	TMQPITFYLA GRLAKKIDRV FILRFGVIFL AAFYLSVLLA GETAASRLVL IGAVLGVGYG 
121:	FYWLAFNVLT FEITEPDTRD FFNGFMGILS SSAGMIGPIV AGFVISRLEN NTGYTVIFSL 
181:	SLSLFALAVV MSFFLKRRES KGRFMLSKVF GERHSNMNWR RITNAHFFQG LREGIFVFLI 
241:	SVFVFIETNS ELALGTFGLV NSAVSFFAYY FASRLIKKKA RKKSILLGGL ILYGALFLIL 
301:	FHMSFSTLLT YGVFIAIGYP LLLVPYVSLT YDVIGRARHA RKARIEYIVL REMFLNAGRI 
361:	VSILCFLLIV ALLKEDVGIP LSLAILGIGH PLIYYFVKDI RFKEKEGENE TMEEDGQKRV 
421:	TEPTLLKGER