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2.A.1.35.1
The fosmidomycin resistance (Fsr) protein (confers fosmidomycin, trimethoprim and carbonylcyanide m-chlorophenylhydrazone (CCCP) resistance) (Fujisaki et al. 1996).

Accession Number:P52067
Protein Name:Fsr aka B0479
Length:406
Molecular Weight:43306.00
Species:Escherichia coli   [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Fosmidomycin, carbonylcyanide m-chlorophenylhydrazone (CCCP)

Cross database links:

Genevestigator: P52067
EchoBASE: EB3054
EcoGene: EG13268
eggNOG: COG0477
HEGENOM: HBG611985
RefSeq: AP_001128.1    NP_415012.1   
Entrez Gene ID: 945119   
Pfam: PF07690   
BioCyc: EcoCyc:FSR-MONOMER    ECOL168927:B0479-MONOMER   
KEGG: ecj:JW0468    eco:b0479   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (4)

[1] “Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification.”  Fujisaki S.et.al.   8917080
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAMSEQPQPV AGAAASTTKA RTSFGILGAI SLSHLLNDMI QSLILAIYPL LQSEFSLTFM 
61:	QIGMITLTFQ LASSLLQPVV GYWTDKYPMP WSLPIGMCFT LSGLVLLALA GSFGAVLLAA 
121:	ALVGTGSSVF HPESSRVARM ASGGRHGLAQ SIFQVGGNFG SSLGPLLAAV IIAPYGKGNV 
181:	AWFVLAALLA IVVLAQISRW YSAQHRMNKG KPKATIINPL PRNKVVLAVS ILLILIFSKY 
241:	FYMASISSYY TFYLMQKFGL SIQNAQLHLF AFLFAVAAGT VIGGPVGDKI GRKYVIWGSI 
301:	LGVAPFTLIL PYASLHWTGV LTVIIGFILA SAFSAILVYA QELLPGRIGM VSGLFFGFAF 
361:	GMGGLGAAVL GLIADHTSIE LVYKICAFLP LLGMLTIFLP DNRHKD