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2.A.1.35.2
The cationic microbial peptide resistance (RosA) protein

Accession Number:Q56877
Protein Name:RosA
Length:410
Molecular Weight:44360.00
Species:Yersinia enterocolitica [34054]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Cationic peptides

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0055085 P:transmembrane transport

References (3)

[1] “Bacterial polysaccharide synthesis and gene nomenclature.”  Reeves P.R.et.al.   9004408
[2] “Molecular and chemical characterization of the lipopolysaccharide O-antigen and its role in the virulence of Yersinia enterocolitica serotype O:8.”  Zhang L.et.al.   9004221
[3] “Temperature-regulated efflux pump/potassium antiporter system mediates resistance to cationic antimicrobial peptides in Yersinia.”  Bengoechea J.A.et.al.   10931306

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTDRSETELP PSVNTQPFDN TKVKRTSFSI LGAISVSHLL NDMIQSLILA IYPLLQAEFS 
61:	LSFAQIGLIT LTYQLTASLL QPLIGLYTDK HPQPYSLPIG MGFTLSGILL LAVATTFPGG 
121:	FTWHAALVGT GSSVFHPESS RVAARLPVAA TVWLSLFLGG RQFRQRLGPL LAAILIAPYG 
181:	KGNVGWFSLA ALLAIVVLLQ VSKWYQQQQR ATYGKVVKVS SAKILPKKTV ISALAILMVL 
241:	IFSKYFYLTS ISSYYTFYLM HKFGVSVQNA QIHLFVFLFA VAAGTIIGGP LGDRIGRKYV 
301:	IWGSILGVAP FTLILPYVSL YWTGVLTVII GLILASAFSA ILVYAQELIP GKVGMVSGLF 
361:	FGFAFGMGGL GAAVLGYVAD LTSIELVYQI CAFLPLLGII TVFLPNIEDK