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2.A.1.4.1
Sugar-P:Pi antiporter (transports many sugar-phosphates - both 1- and 6-P esters)

Accession Number:P0AGC0
Protein Name:Hexose phosphate transport protein UhpT aka B3666
Length:463
Molecular Weight:50607.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: P0AGC0
EchoBASE: EB1047
EcoGene: EG11054
eggNOG: COG2271
HEGENOM: HBG559184
RefSeq: AP_004126.1    NP_418122.1   
Entrez Gene ID: 948201   
Pfam: PF07690   
BioCyc: EcoCyc:UHPT-MONOMER    ECOL168927:B3666-MONOMER   
KEGG: ecj:JW3641    eco:b3666   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Nucleotide sequence of the uhp region of Escherichia coli.”  Friedrich M.J.et.al.   3301805
[2] “Structure and function of the uhp genes for the sugar phosphate transport system in Escherichia coli and Salmonella typhimurium.”  Island M.D.et.al.   1569007
[3] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Topology of the Escherichia coli uhpT sugar-phosphate transporter analyzed by using TnphoA fusions.”  Lloyd A.D.et.al.   2156798
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLAFLNQVRK PTLDLPLEVR RKMWFKPFMQ SYLVVFIGYL TMYLIRKNFN IAQNDMISTY 
61:	GLSMTQLGMI GLGFSITYGV GKTLVSYYAD GKNTKQFLPF MLILSAICML GFSASMGSGS 
121:	VSLFLMIAFY ALSGFFQSTG GSCSYSTITK WTPRRKRGTF LGFWNISHNL GGAGAAGVAL 
181:	FGANYLFDGH VIGMFIFPSI IALIVGFIGL RYGSDSPESY GLGKAEELFG EEISEEDKET 
241:	ESTDMTKWQI FVEYVLKNKV IWLLCFANIF LYVVRIGIDQ WSTVYAFQEL KLSKAVAIQG 
301:	FTLFEAGALV GTLLWGWLSD LANGRRGLVA CIALALIIAT LGVYQHASNE YIYLASLFAL 
361:	GFLVFGPQLL IGVAAVGFVP KKAIGAADGI KGTFAYLIGD SFAKLGLGMI ADGTPVFGLT 
421:	GWAGTFAALD IAAIGCICLM AIVAVMEERK IRREKKIQQL TVA