TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.4.4
Hexose-P:Pi antiporter regulatory protein; senses external glucose-6-P and transports it with high affinity and low efficiency

Accession Number:P09836
Protein Name:UhpC aka B3667
Length:439
Molecular Weight:48257.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Phosphohexoses, phosphate, Hexose-P

Cross database links:

Genevestigator: P09836
EchoBASE: EB1046
EcoGene: EG11053
eggNOG: COG2271
HEGENOM: HBG559184
RefSeq: AP_004125.1    NP_418123.2   
Entrez Gene ID: 948184   
Pfam: PF07690   
BioCyc: EcoCyc:UHPC-MONOMER    ECOL168927:B3667-MONOMER   
KEGG: ecj:JW3642    eco:b3667   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031226 C:intrinsic to plasma membrane
GO:0005624 C:membrane fraction
GO:0005215 F:transporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Nucleotide sequence of the uhp region of Escherichia coli.”  Friedrich M.J.et.al.   3301805
[2] “Structure and function of the uhp genes for the sugar phosphate transport system in Escherichia coli and Salmonella typhimurium.”  Island M.D.et.al.   1569007
[3] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Interplay between the membrane-associated UhpB and UhpC regulatory proteins.”  Island M.D.et.al.   8349544
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLPFLKAPAD APLMTDKYEI DARYRYWRRH ILLTIWLGYA LFYFTRKSFN AAVPEILANG 
61:	VLSRSDIGLL ATLFYITYGV SKFVSGIVSD RSNARYFMGI GLIATGIINI LFGFSTSLWA 
121:	FAVLWVLNAF FQGWGSPVCA RLLTAWYSRT ERGGWWALWN TAHNVGGALI PIVMAAAALH 
181:	YGWRAGMMIA GCMAIVVGIF LCWRLRDRPQ ALGLPAVGEW RHDALEIAQQ QEGAGLTRKE 
241:	ILTKYVLLNP YIWLLSFCYV LVYVVRAAIN DWGNLYMSET LGVDLVTANT AVTMFELGGF 
301:	IGALVAGWGS DKLFNGNRGP MNLIFAAGIL LSVGSLWLMP FASYVMQATC FFTIGFFVFG 
361:	PQMLIGMAAA ECSHKEAAGA ATGFVGLFAY LGASLAGWPL AKVLDTWHWS GFFVVISIAA 
421:	GISALLLLPF LNAQTPREA