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2.A.1.44.1
The L-amino acid transporter-3, LAT3 (transports neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine by a Na+-independent, electroneutral, facilitated diffusion process; also transports amino acid alcohols) (Prostate cancer up-regulated gene product)

Accession Number:O75387
Protein Name:Large neutral amino acids transporter small subunit 3 aka LAT3
Length:559
Molecular Weight:61477.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate L-leucine, L-isoleucine, L-valine, L-phenylalanine, Amino Acid Alcohols

Cross database links:

DIP-47272N
Genevestigator: O75387 O75387
eggNOG: prNOG13750 NOG71084
HEGENOM: HBG444314 HOG000231937
RefSeq: NP_003618.1   
Entrez Gene ID: 8501   
Pfam: PF07690   
OMIM: 603733  gene
KEGG: hsa:8501    hsa:8501   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015175 F:neutral amino acid transmembrane transporte...
GO:0015804 P:neutral amino acid transport
GO:0055085 P:transmembrane transport
GO:0015179 F:L-amino acid transmembrane transporter activity
GO:0015175 F:neutral amino acid transmembrane transporter activity
GO:0006811 P:ion transport

References (10)

[1] “cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer.”  Cole K.A.et.al.   9722952
[2] “Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.”  Babu E.et.al.   12930836
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma.”  Chuaqui R.F.et.al.   9255310
[5] “New insights into testicular germ cell tumorigenesis from gene expression profiling.”  Skotheim R.I.et.al.   11956097
[6] “cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer.”  Cole K.A.et.al.   9722952
[7] “Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.”  Babu E.et.al.   12930836
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma.”  Chuaqui R.F.et.al.   9255310
[10] “New insights into testicular germ cell tumorigenesis from gene expression profiling.”  Skotheim R.I.et.al.   11956097

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ 
61:	DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL 
121:	MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI 
181:	TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA 
241:	LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC 
301:	SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG 
361:	AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI 
421:	SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT 
481:	GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE 
541:	YAANGMGPLK VLSGSEVTA