TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.46.7
UPF0226 protein, YhhS.  Exports arabinose but not xylose (Koita and Rao 2012).  Also may export the herbicide, glyphosate (Staub et al. 2012).

Accession Number:P37621
Protein Name:UPF0226 protein yhhS
Length:405
Molecular Weight:42156.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Arabinose, Glyphosate

Cross database links:

Genevestigator: P37621
EchoBASE: EB2133
EcoGene: EG12219
eggNOG: NOG242435
HEGENOM: HOG000122488
Entrez Gene ID: 947982   
Pfam: PF07690   
KEGG: eco:b3473   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport

References (4)

[1] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPEPVAEPAL NGLRLNLRIV SIVMFNFASY LTIGLPLAVL PGYVHDVMGF SAFWAGLVIS 
61:	LQYFATLLSR PHAGRYADSL GPKKIVVFGL CGCFLSGLGY LTAGLTASLP VISLLLLCLG 
121:	RVILGIGQSF AGTGSTLWGV GVVGSLHIGR VISWNGIVTY GAMAMGAPLG VVFYHWGGLQ 
181:	ALALIIMGVA LVAILLAIPR PTVKASKGKP LPFRAVLGRV WLYGMALALA SAGFGVIATF 
241:	ITLFYDAKGW DGAAFALTLF SCAFVGTRLL FPNGINRIGG LNVAMICFSV EIIGLLLVGV 
301:	ATMPWMAKIG VLLAGAGFSL VFPALGVVAV KAVPQQNQGA ALATYTVFMD LSLGVTGPLA 
361:	GLVMSWAGVP VIYLAAAGLV AIALLLTWRL KKRPPEHVPE AASSS