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2.A.1.48.1
The vacuolar basic amino acid (histidine, lysine and arginine) transporter, Vba1 (catalyzes uptake into the vacuoles (equivalent to efflux from the cytoplasm)) (most similar to family 2.A.1.3; DHA2; 13-14 putative TMSs) (Shimazu et al., 2005)

Accession Number:Q04301
Protein Name:Vba1 aka Permease of basic amino acids in the vacuolar membrane
Length:562
Molecular Weight:62640.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Histidine, lysine, Arginine

Cross database links:

Genevestigator: Q04301
eggNOG: fuNOG04702
HEGENOM: HBG203420
DIP: DIP-888N
RefSeq: NP_013806.1   
Entrez Gene ID: 855113   
Pfam: PF07690   
KEGG: sce:YMR088C   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015174 F:basic amino acid transmembrane transporter ...
GO:0015802 P:basic amino acid transport
GO:0055085 P:transmembrane transport

References (3)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.”  Bowman S.et.al.   9169872
[2] “A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae.”  Shimazu M.et.al.   15572352
[3] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQTLDETSNL LPPPEEAEAP PLEQKFHEYN LALPKFPILF SLWLGSFLSS LDSTIVANIM 
61:	NRVAEEFSES SKKQWIATSF LLTNTAFQPL YGKLSDITGR KSALLTAQFF FGLGCLLTCF 
121:	ARNVTEFSIA RAICGIGAGG LNAISSIAVS DICTARERGV YQGYANIVFG FGQLLGAPLG 
181:	GVFIETIGWR ALFGIQVPVI MLCSVLAIKN INIKLFHVPP MKERYTLKNL SRIDIFGSLS 
241:	LVATISGVLF LCSSQLNKLY LALFTIGSFI VFILVERYYA TEKILPFELL TRSFCLSSAV 
301:	TVISSFVVFG EIFRSPIYLQ LLQNISVTKT GLFLIFPSIS VAVGSLVTGW VLRNTKINLA 
361:	HCAYQIIFGG MIMQLLGLGL GYFLLSHLNP DYTIYDMLES ITFRSNSIWW KLIYVFASVL 
421:	VSFGYACLLV ATLVSIVFTV EKSQQGTMTG VFYLWRSIGN VLGASLTLVS YENSLSSMLW 
481:	NYMFKTKRDD EYHFTKKQYY SLINDSSYLR GPNFPTDIFV RILDVYKKAF LISYIPNIAL 
541:	AAVGIVLSLY LVKHTYKRSS SS