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2.A.1.48.2
The vacuolar basic amino acid (Arg, Lys, His) transporter, Vba2 (Shimazu et al., 2005)

Accession Number:P38358
Protein Name:Vacuolar basic amino acid transporter 2 aka VBA2
Length:474
Molecular Weight:51677.00
Species:Saccharomyces cerevisiae (Baker's yeast). [4932]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Histidine, lysine, Arginine

Cross database links:

Genevestigator: P38358
eggNOG: fuNOG07348
HEGENOM: HBG333935
DIP: DIP-5142N
RefSeq: NP_009852.1   
Entrez Gene ID: 852596   
Pfam: PF07690   
KEGG: sce:YBR293W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015174 F:basic amino acid transmembrane transporter ...
GO:0015802 P:basic amino acid transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[2] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[3] “A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae.”  Shimazu M.et.al.   15572352
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSISNWITTA YLITSTSFQP LYGSFSDALG RRNCLFFANG AFTIGCLACG FSKNIYMLSF 
61:	MRALTGIGGG GLITLSTIVN SDVIPSSKRG IFQAFQNLLL GFGAICGASF GGTIASSIGW 
121:	RWCFLIQVPI SVISSILMNY YVPNQKEYNR QNSSIFQNPG KILRDIDVMG SILIITGLTL 
181:	QLLYLSLGCS TSKLSWTSPS VLLLLVGSVI ILLLFILHER KTSARAIIPM ELVNSSYSVV 
241:	VLSISILVGF ASYAYLFTLP LFFQIVLGDS TAKAGLRLTI PSLFTPVGSL ITGFSMSKYN 
301:	CLRLLLYIGI SLMFLGNFLF LFIEKTSPNW LIGLFLIPAN LGQGITFPTT LFTFIFMFSK 
361:	SDQATATSTL YLFRSIGSVW GVAISAGVIQ LSFAGLLRSN LKGLLDENKI KKLIVQLSAN 
421:	SSYIGSLHGE VKNTVIKSFD EATKRAHLMS TLLSSLALIL CILKDNLAKP KTRR