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2.A.1.48.3
Vacuolar G0 arrest protein, Fnx1; involved in amino acid (e.g., his, lys, ile, asn, etc) uptake into the vacuole (Chardwiriyapreecha et al., 2008).

Accession Number:Q09752
Protein Name:Fnx1
Length:531
Molecular Weight:58058.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

HEGENOM: HBG397042
RefSeq: NP_596009.1   
Entrez Gene ID: 2539786   
Pfam: PF07690   
KEGG: spo:SPBC12C2.13   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015182 F:L-asparagine transmembrane transporter acti...
GO:0015188 F:L-isoleucine transmembrane transporter acti...
GO:0015189 F:L-lysine transmembrane transporter activity
GO:0032975 P:amino acid import into vacuole
GO:0033554 P:cellular response to stress
GO:0070314 P:G1 to G0 transition

References (2)

[1] “The role of fnx1, a fission yeast multidrug resistance protein, in the transition of cells to a quiescent G0 state.”  Dimitrov K.et.al.   9710608
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVDQVNLATE QTSLLYPEVS RKKEELSVNK WTILPALWVG GFLSALDMTI VASLYPVIGS 
61:	EFKLMNNASY IVTAYLITNT AFQPLYGRLS DIFGRRPTVV FANAAFTLGT FWCGISRSLP 
121:	ELCMARALAG IGGGGLGTMS SIISSDIVSL RERGTWQGIT NIVWGIGGSL GGPLGGLIAQ 
181:	RWGWRTAFHF QVPMGILSTI LVAWRVRVKP TVRNSNASLL SRIDYLGSFL LVTGITALVV 
241:	TFNMGGDAFP WVSPVIITLL VSSVLILFAF YWVEKNIAVE PIAPVEILSQ PTPLNVCLGN 
301:	FFNAFCSFVI VYELPLFFET TLLMPSSEAG VRIFPYVIST SVGSLCSGLY MKKTGRYRNL 
361:	VIAGFFFMLM GIVSFAVLTS FGHRTPLILI SLCLAMTGCS YGMNLTSTLI AIISSLAPEE 
421:	QAVATGLSYL FRATGSVIGI SLSQTTTLSI LMKQLASNLK DDPDKDDLIR RLRESISIIP 
481:	NLPKDIQKLV IKSYATAFTW TFALVAIIAF AGFWCSLRIK QFYLHTSVDR S