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2.A.1.48.4
Vacuolar amino acid uptake system, Fnx2 (Chardiwiriyapreecha et al., 2008)

Accession Number:O59726
Protein Name:Fnx2
Length:577
Molecular Weight:62900.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Vacuole1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

RefSeq: NP_596093.1   
Entrez Gene ID: 2541016   
Pfam: PF07690   
KEGG: spo:SPBC3E7.06c   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015182 F:L-asparagine transmembrane transporter acti...
GO:0015188 F:L-isoleucine transmembrane transporter acti...
GO:0015189 F:L-lysine transmembrane transporter activity
GO:0032975 P:amino acid import into vacuole

References (3)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.”  Ding D.-Q.et.al.   10759889
[3] “ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.”  Matsuyama A.et.al.   16823372

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNPRTKSPN TNRGQGLRSE RSALLNDSLS SLNGNSSYDS IKDSSKNNKD VAEVNEYPRR 
61:	PESSVSVVSN SPHRQDAATT NTVSTVSVSK VLPALLLGVV LAALDNTIVA STYTKIGAEF 
121:	GKFSQVSWTA TAYMISCTAF QPLFGKFCDI YGRKKTLLAA YCVFGIGCFL CGTSRSLWQL 
181:	VAARAIAGIG GGGMNSTVSI LMSDIVPLKQ RGTYQGIINV FFAIGSSLGG PVGGYFADQY 
241:	TWRIGFLIQV PLIAIAFLCV YFTLNLPHHN HVSFMTRFRK IDLKGLILLI IGVTTMTCAF 
301:	TLGGNVREWN DPVVISLLIA SSISYLSFVY VEAFVAFEPL APMDVLTERT CLSSYLCNFF 
361:	HSVANFGWIY GMPLFFQSIK NEGAEKSGIR LIPMIIGSSL GSLLGGAVIS LTGNYKKITV 
421:	GSYFFGSVAA LFMLRYGYSN FNWEYAVYPF SGGLGNGIAV TTTLVAIIHA SPSAFQASAI 
481:	ATSYLFRSNG CVLGVSISSS IVQTVLGIKL RKSLDFDVDE LLHHLRKDIS YVHRLPEEIR 
541:	QTVLDALLGS IHYSFLFVSF MFFCAFVCSM FIKNRNL