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2.A.1.49.1
The spinster protein, spin1 or spns1 gene product (involved in synaptic growth regulation; interacts with Bcl-2/Bcl-xL, affecting programmed cell death) (Nakano et al., 2001; Sanyal and Ramaswami, 2002; Yanagisawa et al., 2003).  Probably transports sphingosine-1-phosphate (Fukuhara et al. 2012).

Accession Number:Q9GQQ0
Protein Name:Protein spinster
Length:605
Molecular Weight:65820.00
Species: [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Late endosome membrane1 / Multi-pass membrane protein2
Substrate Sphingosine-1-phosphate

Cross database links:

eggNOG: inNOG04149
RefSeq: NP_524823.1    NP_725530.1    NP_725531.1    NP_725532.1    NP_725533.1   
Entrez Gene ID: 45380   
Pfam: PF07690   
KEGG: dme:Dmel_CG8428   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031902 C:late endosome membrane
GO:0005765 C:lysosomal membrane
GO:0007619 P:courtship behavior
GO:0008333 P:endosome to lysosome transport
GO:0035193 P:larval central nervous system remodeling
GO:0006869 P:lipid transport
GO:0040011 P:locomotion
GO:0048477 P:oogenesis
GO:0007422 P:peripheral nervous system development
GO:0012501 P:programmed cell death
GO:0045924 P:regulation of female receptivity
GO:0045477 P:regulation of nurse cell apoptosis
GO:0008582 P:regulation of synaptic growth at neuromuscu...
GO:0051124 P:synaptic growth at neuromuscular junction
GO:0048488 P:synaptic vesicle endocytosis
GO:0055085 P:transmembrane transport

References (6)

[1] “Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster.”  Nakano Y.et.al.   11340170
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[5] “Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation.”  Sweeney S.T.et.al.   12408844
[6] “Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer.”  Dermaut B.et.al.   15998804

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSLKHQKQSY QPLPTAAAMD NPAMIQSSGS SGSSSSEEGG SREDVANLSP LGLPTTYSSQ 
61:	QLMPSDTDSM EEERHRLRPH HHHHHPLGEH HHIPGIPPSA VVPSRLSSVG RSQWFTVTVL 
121:	CFVNLINYMD RFTIAGVLTD VRNDFDIGND SAGLLQTVFV ISYMVCAPIF GYLGDRYSRP 
181:	WIMAVGVGLW STTTLLGSFM KQFGWFIAFR ALVGIGEASY STIAPTIISD LFVHDMRSKM 
241:	LALFYFAIPV GSGLGYIVGS KTAHLANDWR WALRVTPILG IVAVFLILLI KDPVRGHSEG 
301:	SHNLEATTYK QDIKALVRNR SFMLSTAGFT CVAFVAGALA WWGPSFIYLG MKMQPGNENI 
361:	VQDDVAFNFG VITMLAGLLG VPLGSFLSQY LVKRYPTADP VICAFGLLVS APLLTGACLL 
421:	VNSNSVGTYA LIFFGQLALN LNWAIVADIL LYVVVPTRRS TAEAFQILIS HALGDAGSPY 
481:	LVGAISEAIM KHLHKNPSDS GLTTELRSMS QVAGSAISNA TQVIAEATTS LMETARSSAS 
541:	QEYSDVEQFE GLQYALFSTS FVEVLGGIFF IFTACFIIKD KYNATRGLQD ATAQQQQRDE 
601:	RGQIA