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2.A.1.49.4
Protein Spinster homologue 2 (Spns2 or protein two of hearts).  Transports sphingosine-1-P (S1P) and the immunomodulating agent, FTY720 (Hisano et al. 2011; Nijnik et al. 2012).  S1P is a secreted lipid mediator that functions in vascular development. In the yolk syncytial layer, Spns2 functions in S1P secretion, thereby regulating myocardial precursor migration (Kawahara et al. 2009).

Accession Number:A2SWM2
Protein Name:Protein spinster homolog 2
Length:504
Molecular Weight:54670.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Sphingosine-1-phosphate, FTY720

Cross database links:

eggNOG: NOG265975
HEGENOM: HOG000276167
Entrez Gene ID: 568117   
Pfam: PF07690   
KEGG: dre:568117   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006869 P:lipid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.”  Osborne N.et.al.   19062281
[2] “The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.”  Kawahara A.et.al.   19074308

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MCVESDGCEI EGCSSSDEVH TLSGSMSPAL KSRDLHHCRP GQKFHAALLR CRTPLVAAGI 
61:	LSFGNVLNYM DRYTVAGVLL DIQKQFKVGD SSAGLLQTVF ICSFMVAAPI FGYLGDRFNR 
121:	KIILSCGIFF WSAVTLLSSF ITKEYYWLLV LSRCLVGIGE SSYSSISPTI IGDLFTNNKR 
181:	TVMLSVFYLA IPLGSGLGYI LGSIAKDAGG HWYWALRVSP MLGLTAGTLI LIFVSEPKRG 
241:	SADQPGGRLK TRTSWVCDMK ALAKNRSYVF SSLASAAVSF ATGAFGIWIP QYLVRAQVVQ 
301:	KSAESCTYQP CSSRDSLIFG AITCVTGLLG VVIGAVTTRL CRQKTERADP LVCAVSMLGS 
361:	AIFICLIFVV AKKSIVGAYI CIFIGETLLF LNWAITADIL MYVVIPTRRA TAVAFQGFTS 
421:	HLLGDAGSPY LIGLISDSLQ ESYATSEIWQ FLSLGYALML CPFVIVLGGM FFLATALFFL 
481:	DDRDKAAKQV NQLARPPSTV KVTK