TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.49.6
Sphingosine-1-phosphate/dehydroshpingosine-1-P transport protein, Spinster 2. Involved in immune development and lymphocyte trafficing (Nijnik et al. 2012; Fukuhara et al. 2012). 

Accession Number:Q8IVW8
Protein Name:Protein spinster homolog 2
Length:549
Molecular Weight:58044.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Sphingosine-1-phosphate, Dehydroshpingosine-1-P

Cross database links:

Genevestigator: Q8IVW8
eggNOG: COG0477
HEGENOM: HOG000276167
Entrez Gene ID: 124976   
Pfam: PF07690   
KEGG: hsa:124976   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006869 P:lipid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.”  Kawahara A.et.al.   19074308

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MMCLECASAA AGGAEEEEAD AERRRRRRGA QRGAGGSGCC GARGAGGAGV SAAGDEVQTL 
61:	SGSVRRAPTG PPGTPGTPGC AATAKGPGAQ QPKPASLGRG RGAAAAILSL GNVLNYLDRY 
121:	TVAGVLLDIQ QHFGVKDRGA GLLQSVFICS FMVAAPIFGY LGDRFNRKVI LSCGIFFWSA 
181:	VTFSSSFIPQ QYFWLLVLSR GLVGIGEASY STIAPTIIGD LFTKNTRTLM LSVFYFAIPL 
241:	GSGLGYITGS SVKQAAGDWH WALRVSPVLG MITGTLILIL VPATKRGHAD QLGDQLKART 
301:	SWLRDMKALI RNRSYVFSSL ATSAVSFATG ALGMWIPLYL HRAQVVQKTA ETCNSPPCGA 
361:	KDSLIFGAIT CFTGFLGVVT GAGATRWCRL KTQRADPLVC AVGMLGSAIF ICLIFVAAKS 
421:	SIVGAYICIF VGETLLFSNW AITADILMYV VIPTRRATAV ALQSFTSHLL GDAGSPYLIG 
481:	FISDLIRQST KDSPLWEFLS LGYALMLCPF VVVLGGMFFL ATALFFVSDR ARAEQQVNQL 
541:	AMPPASVKV