TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.5.3
Sucrose:H+ symporter, CscB, also transports maltose (Peng et al. 2009). CscB recognizes not just sucrose but also fructose and lactulose, but glucopyranosides are not transported and do not inhibit sucrose transport (Sugihara et al. 2011).

Accession Number:P30000
Protein Name:CscB
Length:415
Molecular Weight:46924.00
Species:Escherichia coli [562]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Sucrose, Maltose, H+

Cross database links:

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport

References (1)

[1] “Characterization of a chromosomally encoded, non-PTS metabolic pathway for sucrose utilization in Escherichia coli EC3132.”  Bockmann J.et.al.   1435727

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MALNIPFRNA YYRFASSYSF LFFISWSLWW SLYAIWLKGH LGLTGTELGT LYSVNQFTSI 
61:	LFMMFYGIVQ DKLGLKKPLI WCMSFILVLT GPFMIYVYEP LLQSNFSVGL ILGALFFGLG 
121:	YLAGCGLLDS FTEKMARNFH FEYGTARAWG SFGYAIGAFF AGIFFSISPH INFWLVSLFG 
181:	AVFMMINMRF KDKDHQCIAA DAGGVKKEDF IAVFKDRNFW VFVIFIVGTW SFYNIFDQQL 
241:	FPVFYAGLFE SHDVGTRLYG YLNSFQVVLE ALCMAIIPFF VNRVGPKNAL LIGVVIMALR 
301:	ILSCALFVNP WIISLVKLLH AIEVPLCVIS VFKYSVANFD KRLSSTIFLI GFQIASSLGI 
361:	VLLSTPTGIL FDHAGYQTVF FAISGIVCLM LLFGIFFLSK KREQIVMETP VPSAI