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2.A.1.5.5
The melibiose uptake porter of 425 aas and 12 TMSs. Takes up lactose and melibiose, but in contrast to LacY of E. coli, it binds, but does not transport thiomethyl-β-galactoside,TMG (Tavoulari and Frillingos 2008).

Accession Number:P96517
Protein Name:MelY
Length:425
Molecular Weight:46701.00
Species:Enterobacter cloacae [550]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Gene Ontology

GO:0016020 C:membrane
GO:0006810 P:transport

References (2)

[1] “A melibiose transporter and an operon containing its gene in Enterobacter cloacae.”  Okazaki N.et.al.   9209070
[2] “Sequence of a melibiose transporter gene of Enterobacter cloacae.”  Okazaki N.et.al.   9375783

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTTTCTHKD NPNFWIFGLF FFLYFFIMAT CFPFLPIWLS DIIGLNKTHT GIVFSCISLS 
61:	AIAFQPVLGV ISDKLGLKKH LLWIISVLLF LFAPFFLYVF APLLKTNIWL GALSGGLYIG 
121:	FVFSAGSGAI EAYIERVSRN SAFEYGKARM FGCLGWGLCA STGGILFGID PSYVFWMGSA 
181:	AALLLMLLLV VAKPKPNQTA QVMNALGANQ PQITAKKVFN LFRQRRMWMF ILYVIGVACV 
241:	YDVFDQQFAT FFKTFFATPQ EGTRAFGFAT TAGEICNAII MFCSPWIINR IGAKNTLLIA 
301:	GLIMATRIIG SSFATTAVEV IALKMLHALE VPFLLVGAFK YITGVFDTRL SATIYLIGFQ 
361:	FAKQSAAIFL SAFAGNMYDR IGFQETYLML GCFVLAITVV SAFTLSSRQE IAAAAGAAAL 
421:	TSQSR