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2.A.1.50.2
Thymic stromal cotransporter, TSCOT (Kim et al. 2000)

Accession Number:Q9BY10
Protein Name:Thymic stromal cotransporter homolog aka TSCOT
Length:475
Molecular Weight:51067.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Genevestigator: Q9BY10 Q9BY10
eggNOG: prNOG10674 NOG264356
HEGENOM: HBG715481 HOG000231710
RefSeq: NP_149040.3   
Entrez Gene ID: 57864   
Pfam: PF07690   
OMIM: 608956  gene
KEGG: hsa:57864    hsa:57864   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport
GO:0009986 C:cell surface

References (6)

[1] “Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology.”  Chen C.et.al.   10978518
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology.”  Chen C.et.al.   10978518
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPEVTCPRR GHLPRFHPRT WVEPVVASSQ VAASLYDAGL LLVVKASYGT GGSSNHSASP 
61:	SPRGALEDQQ QRAISNFYII YNLVVGLSPL LSAYGLGWLS DRYHRKISIC MSLLGFLLSR 
121:	LGLLLKVLLD WPVEVLYGAA ALNGLFGGFS AFWSGVMALG SLGSSEGRRS VRLILIDLML 
181:	GLAGFCGSMA SGHLFKQMAG HSGQGLILTA CSVSCASFAL LYSLLVLKVP ESVAKPSQEL 
241:	PAVDTVSGTV GTYRTLDPDQ LDQQYAVGHP PSPGKAKPHK TTIALLFVGA IIYDLAVVGT 
301:	VDVIPLFVLR EPLGWNQVQV GYGMAAGYTI FITSFLGVLV FSRCFRDTTM IMIGMVSFGS 
361:	GALLLAFVKE TYMFYIARAV MLFALIPVTT IRSAMSKLIK GSSYGKVFVI LQLSLALTGV 
421:	VTSTLYNKIY QLTMDMFVGS CFALSSFLSF LAIIPISIVA YKQVPLSPYG DIIEK