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2.A.1.50.4
Multidrug efflux transporter, MET, of 507 aas and 12 TMSs (Chahine et al. 2012).  Exposure to dietary methotrexate was associated with increased fluid secretion rate and increased flux of methotrexate, but not salicylate. Exposure to methotrexate in the diet resulted in increases in the expression of a multidrug efflux transporter gene (MET; CG30344) in the Malpighian tubules. There were also increases in expression of genes for either a Drosophila multidrug resistance-associated protein (dMRP; CG6214; TC# 3.A.1.208.39) or an organic anion transporting polypeptide (OATP; CG3380; TC# 2.A.60.1.27), depending on the concentration of methotrexate in the diet.  MET probably does not export methotrexate (Chahine et al. 2012).

Accession Number:Q961H2
Protein Name:GH23453p
Length:507
Molecular Weight:55904.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:10
Substrate drugs

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPRSDTEALV ADVETGEDSA PRILDASSAA SSEQVDPPPV PPPHDYSSYR WFILEPAVFL 
61:	IFFARNLIGA VYQNQILYQT CITIEKFNAT QCEPLLGIDR GSDADKEVEV IVQTYSANIM 
121:	MTTSLLESII PAFASLFLGP WSDKFGRRPI LLTTFTGYLT GALILIVITY ITRSTNISPW 
181:	WFLLSSVPSV VSGGTCALIT GIYCYISDVA KERKKALRMV LNEASLCAGI MVGNVASGYI 
241:	YAATNALVLF SIAGSLMMFA LMYVLLFVPE SLNPGDIHTG SRVREFFRFD LVTDLIRTCF 
301:	KRRPNFDRTI IWLTMIALTI AIFDMEGEST VNYMFVQDKF NWTIKDFSLF NASRIVIQIV 
361:	GSIVGMLVLR RVLKMSIVTM AMLSLACCVL ESTVRATAVY WQELYLGMTL GMMRGVMGPM 
421:	CRAILSHVAP ATEVGKIFAL TTSMESVSPL GAAPLYTTVY KATLENYPGA FNFISAALYF 
481:	VCYILIAVIF GIQKSMGSSS VYQAIGS