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2.A.1.53.1
The threonine uptake permease, PhtA (Sauer et al., 2005) (required for maximal growth in macrophages and Acanthamoeba castellanii)

Accession Number:Q5ZY33
Protein Name:PhtA
Length:427
Molecular Weight:46395.00
Species:Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152)   [272624]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Threonine

Cross database links:

eggNOG: COG0477
HEGENOM: HBG613383
RefSeq: YP_094583.1   
Entrez Gene ID: 3078478   
Pfam: PF07690   
BioCyc: LPNE272624:LPG0540-MONOMER   
KEGG: lpn:lpg0540   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (1)

[1] “The genomic sequence of the accidental pathogen Legionella pneumophila.”  Chien M.et.al.   15448271

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGISKVEIYK RKNYLGFAWL VWGLAAAFYF SDYLARVAPG VMHRYLQMDF GINEAGFGIL 
61:	TASFYVPYIL MQIPVGLTVD RLSIRWLLTI MSLVTAFGCC VFGLADGLLT ASIGRMLIGF 
121:	SAAFAFICSL RLATSWFPPT MLGLLSGLTQ ALGMLGAAAG EAPVSFLVSN VGWRHSMLII 
181:	AFLFIALSGL LYQFVQDKPG EHRNEIRSVN RISILDSLKI ILSNKQTWLN AMYAGFLFGP 
241:	TAVIGEAIGP AYLQFGRGLG AHAAAFATGL IFIGWGISGP LSGWISDKMG RRKPLMIISA 
301:	VCGVILSSLF VFIPEMSQTT AYILFFVFGL TNTGVAISYA VSTEIHDRSV VGTSIAFTNM 
361:	TSIFVGALFQ PLVGRIIDMV SGPRAYNVET LLLSDFQAGL KLLPLCSLVA LILAFTVKET 
421:	YCKPIRH