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2.A.1.53.6
MFS uptake permease specific for pyrimidines, PhtC of 422 aas and 12 TMSs.  Together with PhtD (TC# 2.A.1.53.6), it contributes to protection of L. pneumophila from dTMP starvation, protects the cell from 5-fluorodeoxyuridine (FUdR) toxicity and is required for growth of L. pneumophila in macrophage (Fonseca et al. 2014).

Accession Number:I7I0I1
Protein Name:Major facilitator family transporter
Length:422
Molecular Weight:46477.00
Species:Legionella pneumophila subsp. pneumophila [91891]
Number of TMSs:12
Substrate Pyrimidines

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSHSVAVESK TFVPRGDFMA WVVCLSAGLF FLYEFFQLNI FDVINQSLRE DFHIDATQLS 
61:	WMSSTYLWAD ILFLLPAGLI LDRFSTRKVI LTAMFVCVVG TIGFAVTESF FLASFFHFLS 
121:	GIGNAFCFLS CVVLVSHWFP PRRQALVIGS LVTMAFIGGM MAHTPFAYLN DLFGWRRALL 
181:	IDGVVGAFLI LWIYMIVQDR PEESPAHKLT NEGQILSSFM KALSNKQNWL AGLYTSLLNL 
241:	PIMVLCALWG ASYLQVAHHL PDIAASNVVS LIFMGSVVGC PLVGWLSDTQ GRRKPLMIFG 
301:	AIATLITTIP LFINVVLTQM SLSILFFALG LFTSTQVISY PLVAESNQPE NTGAATGIAS 
361:	VIIMGGGGVA QVLFGWLMTH HAGTNVTAYT VSDFQFAMWM FPVAAIAGLV AVLMTRETYC 
421:	KR