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2.A.1.53.7
MFS uptake permease, probably specific for pyrimidines, PhtD of 427 aas and 12 TMSs.  Together with PhtC (TC# 2.A.1.53.6), it contributes to protection of L. pneumophila from dTMP starvatioin, protects the cell from 5-fluorodeoxyuridine (FUdR) toxicity and is required for growth of L. pneumophila in macrophage (Fonseca et al. 2014).

Accession Number:I7HKH2
Protein Name:Major facilitator family transporter
Length:427
Molecular Weight:47051.00
Species:Legionella pneumophila subsp. pneumophila [91891]
Number of TMSs:12
Substrate Pyrimidines, 5-fluorodeoxyuridine

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQVVDEFKAF DVKASLMPWL VCFAATMFFF YEFIQGNMFA SIAANIMQDF QIQADKMAYL 
61:	SSIYYLANVI FLFIAGMVLD RFSIKNTILI AMFLCVISTF ILSYSDSFYV ALFCRFVTGI 
121:	GSAFCFLGPV RLASHWFPPQ RMALVTGAIV TVAMTGGMLA QYPLTKLVLY VGWRQAVQDV 
181:	GILGLAMLVL MFFWIKERPQ VAIKKEGKPI NVLVAARKAY LNAQNLRAAL YTSLMNMAIA 
241:	VFGAMMGTLY LEQRLGISPD QAAMINGMLF FGAIIGSPLM GWISDKVGLR VLPMKGGVLA 
301:	SLFILLGVLY LPVSVTMMAV LFFLLGLFTS AQVISYALVA ESSPPMMTAT AVSVVSILTQ 
361:	GGYLIYQNLF SALLTNYGDV RLINGVPVYL LEAYQHAAII LPIGLLIALL LLFGLKETRC 
421:	QQVEHTV