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2.A.1.6.2
α-Ketoglutarate (oxoglutarate):H+ symporter (Seol and Shatkin 1992; Seol and Shatkin 1992).  May also export arabinose but not xylose (Seol and Shatkin 1992).  May also export arabinose but not xylose (Koita and Rao 2012).

Accession Number:P0AEX3
Protein Name:Alpha-ketoglutarate permease KgtP aka WITA aka B2587
Length:432
Molecular Weight:47052.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Arabinose, H+, Alpha-ketoglutarate

Cross database links:

Genevestigator: P0AEX3
EchoBASE: EB0517
EcoGene: EG10522
eggNOG: COG0477
HEGENOM: HBG757988
RefSeq: AP_003173.1    NP_417082.1   
Entrez Gene ID: 947069   
Pfam: PF00083   
BioCyc: EcoCyc:KGTP-MONOMER    ECOL168927:B2587-MONOMER   
KEGG: ecj:JW2571    eco:b2587   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0055085 P:transmembrane transport

References (9)

[1] “A new gene located between pss and rrnG on the Escherichia coli chromosome.”  Seol W.et.al.   2118499
[2] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Transcriptional termination sequence at the end of the Escherichia coli ribosomal RNA G operon: complex terminators and antitermination.”  Albrechtsen B.et.al.   1709493
[6] “Sequence of the distal end of E. coli ribosomal RNA rrnG operon.”  Seol W.et.al.   2190187
[7] “Escherichia coli kgtP encodes an alpha-ketoglutarate transporter.”  Seol W.et.al.   2053984
[8] “Membrane topology model of Escherichia coli alpha-ketoglutarate permease by phoA fusion analysis.”  Seol W.et.al.   8419306
[9] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAESTVTADS KLTSSDTRRR IWAIVGASSG NLVEWFDFYV YSFCSLYFAH IFFPSGNTTT 
61:	QLLQTAGVFA AGFLMRPIGG WLFGRIADKH GRKKSMLLSV CMMCFGSLVI ACLPGYETIG 
121:	TWAPALLLLA RLFQGLSVGG EYGTSATYMS EVAVEGRKGF YASFQYVTLI GGQLLALLVV 
181:	VVLQHTMEDA ALREWGWRIP FALGAVLAVV ALWLRRQLDE TSQQETRALK EAGSLKGLWR 
241:	NRRAFIMVLG FTAAGSLCFY TFTTYMQKYL VNTAGMHANV ASGIMTAALF VFMLIQPLIG 
301:	ALSDKIGRRT SMLCFGSLAA IFTVPILSAL QNVSSPYAAF GLVMCALLIV SFYTSISGIL 
361:	KAEMFPAQVR ALGVGLSYAV ANAIFGGSAE YVALSLKSIG METAFFWYVT LMAVVAFLVS 
421:	LMLHRKGKGM RL