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2.A.1.6.8
The acetate/monochloroacetate (haloacid) permease, Deh4p (Km = 5.5 mμM for acetate; 9 mμM for monochloroacetate) (Yu et al., 2007; Su and Tsang 2012).

Accession Number:Q7X4L6
Protein Name:Deh4p
Length:552
Molecular Weight:59415.00
Species:Burkholderia cepacia GN=deh4p PE=4 SV=1 [292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Acetate, Monochloroacetate

Cross database links:

Pfam: PF00083   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (2)

[1] “Use of ribosomal promoters from Burkholderia cenocepacia and Burkholderia cepacia for improved expression of transporter protein in Escherichia coli.”  Yu M.et.al.   16737826
[2] “Isolation and Characterization of a Novel Haloacid Permease from Burkholderia cepacia MBA4.”  Yu M.et.al.   17545323

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATIEGRAAP APITSEERRV IFASSLGTVF EWYDFYLAGS LAIYISRTFF SGVNPAAGFV 
61:	FTLLGFAAGF AVRPFGAIVF GRLGDMIGRK YTFLATILLM GLSTFVVGLL PGYGTIGMTA 
121:	PVVFIAMRML QGLALGGEYG GAATYVAEHA PSNKRGAWTA WIQTTATLGL FISLLVILSV 
181:	RSLLNEDTFA AWGWRVPFLV SIVLLAVSVW IRMQLHESPV FERIKAEGKT SKAPLSEAFG 
241:	QWKNLKIVLL ALFGLTAGQA VVWYTGQFYT LFFLTQTLKV DGTSANMLVA VALLIGTPFF 
301:	LFFGSLSDKI GRKPIIMAGC LIAALTYFPL FKALAHYTNP KLEAATLQAP ITMIADPSEC 
361:	SFQFNPVGTA KFTSSCDVAK GALSKAGLNY ENITAPAGTV AQIRIGDKVV DAYDGKAADA 
421:	KARGAEFEQT LSKSLETAGY PAKADPALIN WPMSILILTI LVLYVTMVYG PLAAMLVEMF 
481:	PARIRYTSMS LPYHIGNGWF GGFLPATAFA IIAARGNIYS GLWYPIVIAS VAFVIGTLFV 
541:	KETKGSSTYD AD