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2.A.1.65.1
The putative MFS carrier, Sugar Baby (Sug, isoform D); has a hydrophilic domain between TMSs 3 and 4. Overexpression causes an increased lifespan by 17%.

Accession Number:Q7KUF9
Protein Name:Sug, isoform D
Length:625
Molecular Weight:69510.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

eggNOG: inNOG07680
RefSeq: NP_996057.2   
Entrez Gene ID: 39314   
Pfam: PF07690   

Gene Ontology

GO:0008340 P:determination of adult lifespan
GO:0055085 P:transmembrane transport

References (2)

[1] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKATIDKELL PMKAHYFLFN AGTAPVVPFM PTLAGQLGYS PAVVGTMYTI LPIIGMLAKP 
61:	LFGYIADRYH RHRPLFLGGQ VLTGIAFFLI MFVPGMEKPL PKVEFHCHQG VSDIPRFCSE 
121:	YGECVERNLE RYYGNRTLEC ELNCEAQPFM WDIVCEDWLK NNTENCAANR TNTQMEFGAS 
181:	ITMQKIENDG SCMFFMIPHD QGQIAGQNVT LYCPKEKEYF KSNCTMDCRE DYLKEQLAES 
241:	AVINTSSAVT MPQFWLFFGL LIFSWIGMAV VVSIGDAICF GILGDRHHLY GKQRLCGSLG 
301:	WGVFALLAGL LVDHMSLGEV NKNYTAVFWM ALLIMGFDVF ASSKLRVSIS ETENPFLKLK 
361:	FPYSKLQHTP THLSSNILKD VGQMFLSVRC VIFFLWCVAI GLGTALIWNF LFIYLEELDK 
421:	AFEGCDSSIK TLEGLVMGIQ CFGGELPFFF LSGWILKKIG HVNAMSVVLF GFGVRFILYS 
481:	MLQNPWYILP IELMNGVTFG LFYATMASYA SIVAPPGTDA TMQSLVGAIF EGVGVSMGSL 
541:	IAGQLFESVT ARTTFEIFGI GAFIVFVIHV CIQLYLQRNS NIDENGKGTV ASASATASPS 
601:	APLETDIPKN TDHKDGDGFR EVDLS