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2.A.1.65.6
Macrophage MHC Class I receptor 2, Mmr2 or MFSD6

Accession Number:Q8CBH5
Protein Name:Major facilitator superfamily domain-containing protein 6
Length:775
Molecular Weight:86076.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q8CBH5 Q8CBH5
eggNOG: roNOG07365 roNOG07365
HEGENOM: HBG447155 HBG447155
Entrez Gene ID: 98682   
Pfam: PF07690   
KEGG: mmu:98682    mmu:98682   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0004872 F:receptor activity
GO:0055085 P:transmembrane transport

References (8)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice.”  Tashiro-Yamaji J.et.al.   17010536
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319
[5] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[6] “Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice.”  Tashiro-Yamaji J.et.al.   17010536
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MAADDKVAIL TDDEEEQKRK YVLADPFNGI CREPEPPSNE TPSSTETSAI PEEEIDWIEK 
61:	HCVKVNNDLL ISKVFYFFFY SAYGSLYPLL PVYYKQLGMS PSQSGLLVGI RYFIEFCSAP 
121:	FWGVVADRFR KGKIVLLFSL LCWVLFNLGI GFVKPATLRC LPKIPPTAHP TNVSHPVTVL 
181:	PMNSSTVAFF STPPKLLQKR DVQLSETEPN ISDIDLVSTA LTLTSEPTRR PQTEAITHPV 
241:	TGLILNTSTV TLPPTGNVTR ETTIAVVTTT KSLPSDQVTL VYDQQEVEAI FLIILVVVII 
301:	GEFFSASSVT IVDTVTLQYL GKHRDRYGLQ RMWGSLGWGL AMLSVGIGID YTHIDVLIDG 
361:	KGCKPPEYRN YQIVFIVFGV LMTMALIVAT QFRFRYNHFN NSDGKGKEVE IPQVERDNST 
421:	ESSEETPTAA THSQAFNFWD LIKLLCSVQY GSVLFVAWFM GFGYGFVFTF LYWHLEDLNG 
481:	TTTLFGVCSV LSHVSELTAY FFSHKLIELI GHIRVLYIGL ACNTARYIYI SYLENAWTVL 
541:	PMEVLQGVTH AAIWAACISY LSAAVPPELR TSAQGILQGL HLGLGRGCGA MIGGVLVNYF 
601:	GAAATFRGIG MACLVILLLF ALIQWLAVPD EEEDKTMLAE RIPVPSSPVP IATIDLVQQQ 
661:	TEDVMPRVEA RLPPKKTKHQ EEQEDVNKPA WGVSSSPWVT FVYALYQVKE LIQLTRESRA 
721:	SEIQPLQVTL CWASVASAPL LPPCSSKHMG NRKTGMLAKD ISGLRSLCHS VYQVA