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2.A.1.66.1
MFS permease of unknown function (First half resembles 2.A.1.3.7 (e-11) and 2.A.1.15.3 (e-8)). Very likely to be a galactoside/galactose transporter; encoded within a gene cluster with β-galactosidase and galactose metabolic genes.

Accession Number:A1RW34
Protein Name:Major facilitator superfamily MFS_1
Length:428
Molecular Weight:46528.00
Species:Thermofilum pendens (strain Hrk 5) [368408]
Number of TMSs:12
Substrate Galactose, Galactosides

Cross database links:

eggNOG: COG0477
HEGENOM: HBG529991
Entrez Gene ID: 4601889   
Pfam: PF07690   
KEGG: tpe:Tpen_0004   

Gene Ontology

GO:0055085 P:transmembrane transport

References (1)

[1] “Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.”  Anderson I.et.al.   18263724

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPEGRPRVKV IVASLALFVL FYFMGYYMLN PILRTLHAEG LIPGKSEVEW RFNAGLIATL 
61:	LQGTGLVLSF VWGVLADKVG RRPVIFTLGV IMGLGLLLVS QARSYAELLA YFIAFGVGYV 
121:	GVGPAIYAFI SDALPSESRG RGYASYYVSS VLAMILGLIV AGVLLPWRTA YMLAGLLTLV 
181:	FSVLLFYSSR GIFIGYSEKG AREARRYSLR ESLPSLRKKS VLLVLLMIIP WTIPWGMLSI 
241:	WSIDYISTKW GVSTGTASLI IAAATASIAL GHIVGGTLSD RLAGKGDYTG RTKVSLLGVV 
301:	VGYVSMMLMV TYPYPYGSTN FKDLLVPSAL AVGGMMFTTF AYPNINTVLS EVVVPEHRGT 
361:	VFAVYSVLNN LGWTLGPTVY TLLLKAFSGV YADQVSAMTA AASTIVSLWL IPALCWLLLH 
421:	RVYPKEKI