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2.A.1.7.1
L-Fucose:H+ symporter. The x-ray structure (3.1Å resolution) with an outward open, amphipathic cavity has been solved. Asp46 and Glu135 can undergo cycles of protonation (Dang et al., 2010). 

Accession Number:P11551
Protein Name:FucP aka B2801
Length:438
Molecular Weight:47545.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate L-fucose, H+

Cross database links:

Genevestigator: P11551
EchoBASE: EB0348
EcoGene: EG10352
eggNOG: COG0738
HEGENOM: HBG735535
RefSeq: AP_003367.1    NP_417281.1   
Entrez Gene ID: 947487   
Pfam: PF07690   
BioCyc: EcoCyc:FUCP-MONOMER    ECOL168927:B2801-MONOMER   
KEGG: ecj:JW2772    eco:b2801   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015518 F:arabinose:hydrogen symporter activity
GO:0015535 F:fucose:hydrogen symporter activity
GO:0015517 F:galactose:hydrogen symporter activity
GO:0015751 P:arabinose transport
GO:0015755 P:fructose transport
GO:0006004 P:fucose metabolic process
GO:0015756 P:fucose transport
GO:0015757 P:galactose transport
GO:0055085 P:transmembrane transport

References (8)

[1] “The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation.”  Lu Z.et.al.   2664711
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol.”  Chen Y.M.et.al.   2553671
[5] “Identification of a novel sugar-H+ symport protein, FucP, for transport of L-fucose into Escherichia coli.”  Gunn F.J.et.al.   8052131
[6] “Proton-linked L-fucose transport in Escherichia coli.”  Bradley S.A.et.al.   2829831
[7] “Topological analyses of the L-fucose-H+ symport protein, FucP, from Escherichia coli.”  Gunn F.J.et.al.   7783647
[8] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
Structure:
3O7P   3O7Q     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGNTSIQTQS YRAVDKDAGQ SRSYIIPFAL LCSLFFLWAV ANNLNDILLP QFQQAFTLTN 
61:	FQAGLIQSAF YFGYFIIPIP AGILMKKLSY KAGIITGLFL YALGAALFWP AAEIMNYTLF 
121:	LVGLFIIAAG LGCLETAANP FVTVLGPESS GHFRLNLAQT FNSFGAIIAV VFGQSLILSN 
181:	VPHQSQDVLD KMSPEQLSAY KHSLVLSVQT PYMIIVAIVL LVALLIMLTK FPALQSDNHS 
241:	DAKQGSFSAS LSRLARIRHW RWAVLAQFCY VGAQTACWSY LIRYAVEEIP GMTAGFAANY 
301:	LTGTMVCFFI GRFTGTWLIS RFAPHKVLAA YALIAMALCL ISAFAGGHVG LIALTLCSAF 
361:	MSIQYPTIFS LGIKNLGQDT KYGSSFIVMT IIGGGIVTPV MGFVSDAAGN IPTAELIPAL 
421:	CFAVIFIFAR FRSQTATN