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2.A.1.7.4
Rat kidney Na+-dependent glucose (methyl α-glucoside) transporter, NaGLT1 (glucose:Na+:Na+=1:1) (Horiba et al., 2003)

Accession Number:Q80T22
Protein Name:NaGLT1
Length:484
Molecular Weight:51775.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q80T22
eggNOG: roNOG15543
RefSeq: NP_788269.1   
Entrez Gene ID: 337920   
Pfam: PF07690   
KEGG: rno:337920   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0005355 F:glucose transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney.”  Horiba N.et.al.   12590146
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEFRGSGATA VEQHLLQSET PGKNGLQATS SDQVGRTLRW FTTVVLNAAF LGMGVSAAVL 
61:	GPTFPDLARN VNRNISSLSE IFVGRALGYL GGSVVGGVLF DCMNHFLLLG LSHLLTAAGL 
121:	YLTPFCKTAA LLTAMMSITG VSFGVLDTGG NVLILDLWGD KGAPHIQALH FSFALGAFLA 
181:	PLLAKLAWGT TASAQNHTEP QLDRSALNRS FEAASDSVLA VPDDMNLLWA YASIGTYVLV 
241:	LSVFLFAPFF KKRSKQKKSA ASAQGARRAK YHRALLCLLF LFFFFYVGAE VTYGSYVFSF 
301:	ATTHVGMEES EAAGLNSIFW GTFAACRGLA IFFATLLQPG TMMVLCNIGS LASSFFLVLF 
361:	DKSPLCLWIA SSVYGASMAA TFPSGISWIE QYTTLTGKSA AFILVGAALG LMATPALSGI 
421:	LQGHYPDLPV ILYMCLGSAV LTTVLFPVMY KVATLPLDRK QEKSINSEGQ KILLSSSRLI 
481:	KEAK