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2.A.1.7.7
The Na+-dependent sugar transporter, HP1174 (transports glucose, galactose, mannose and 2-deoxyglucose (Psakis et al. 2009)). (most similar to 2.A.1.7.2; 49% identity)

Accession Number:O25788
Protein Name:Putative glucose/galactose transporter
Length:407
Molecular Weight:43950.00
Species:Helicobacter pylori [210]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate glucose, 2-deoxyglucose, Mannose, Galactose

Cross database links:

HEGENOM: HBG735535
RefSeq: NP_207965.1   
Entrez Gene ID: 899934   
Pfam: PF07690   
KEGG: hpy:HP1174   

Gene Ontology

GO:0009276 C:Gram-negative-bacterium-type cell wall
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005354 F:galactose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0015757 P:galactose transport
GO:0015758 P:glucose transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The complete genome sequence of the gastric pathogen Helicobacter pylori.”  Tomb J.-F.et.al.   9252185

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQKTSNTLAL GSLTALFFLM GFITVLNDIL IPHLKPIFDL TYFEASLIQF CFFGAYFIMG 
61:	GVFGNVISKI GYPFGVVLGF VITATGCALF YPAAHFGSYG FFLGALFILA SGIVCLQTAG 
121:	NPFVTLLSKG KEARNLVLVQ AFNSLGTTLG PIFGSLLIFS TTKMGDNASL IDKLADAKSV 
181:	QMPYLGLAVF SLLLALIMYL LKLPDVEKEM PKETTQKSLF SHKHFVFGAL GIFFYVGGEV 
241:	AIGSFLVLSF EKLLNLDSQS SAHYLVYYWG GAMVGRFLGS VLMNKIAPNK YLAFNALSSI 
301:	VLIALAIIIG GKIALFALTF VGFFNSIMFP TIFSLATLNL GHLTSKASGV ISMAIVGGAL 
361:	IPPIQGAVTD MLTATESNLL YAYGVPLLCY FYILFFALKG YKQEENS