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2.A.1.70.9
ArsK, exporter of arsenite, antimonite, trivalent roxarsone and methylarsenite (Shi et al. 2018). Expression of arsK is induced by arsenite [As(III)], antimonite [Sb(III)], trivalent roxarsone [Rox(III)], methylarsenite [MAs(III)] and arsenate [As(V)], and heterologous expression of ArsK in an arsenic-hypersensitive E. coli strain showed that ArsK is essential for resistance to As(III), Sb(III), Rox(III) and MAs(III) but not to As(V), dimethylarsenite [Dimethyl-As(III)] or Cd(II). ArsK reduces the cellular accumulation of As(III), Sb(III), Rox(III) and MAs(III) but not to As(V) or Dimethyl-As(III). An arsenic regulator gene arsR2 is cotranscribed with arsK, and ArsR2 interacts with the arsR2-arsK promoter region without metalloids but is derepressed by As(III), Sb(III), Rox(III) and MAs(III). Thus, ArsK is an arsenic efflux protein  and is regulated by ArsR2 (Shi et al. 2018).  

Accession Number:WP_112681627
Protein Name:WP_112681627.1 arsenite efflux MFS transporter ArsK [Agrobacterium tumefaciens]
Length:404
Molecular Weight:
Species:Agrobacterium tumefaciens [358]
Substrate

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FASTA formatted sequence
1:	MSLHNSKVPA GIVSALGLTQ IIGYGTLYYS FSILAPGMAE DLGLTLAEVF GVFSVSLFIG 
61:	GLSATYIGRQ MDRIGAATVM TVGSGLAALM LSLCAWSPSV AIFAVAIILL EVSSGMVQYQ 
121:	AAFATLVESD PRTASRSITY LTLIGGFAST IFWPISAALS EWMSWREIYL VFAALNLFLC 
181:	MPLHVWIMRV GKTGPNADAA VPREAIIGAI PHDARRRSMI MVSFAFALLG FSLAAILAHM 
241:	VPMLGSIGLG GAAVVIGSLF GPAQVASRLI NMVFGKNLSP PALAVLSAVL IVFGILILLA 
301:	TRDWLPGAVA FAICLGLGSG INSIAQGSLP LYLFGSEGYG AITGKMAAAR LALGAGAPFA 
361:	FAASMENFGL SLSLIGNACL GAVSITAFVA VAASCRRPAT ATT