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2.A.1.71.1
The Valanimycin-resistance determinant, VlmF (probably a valanimycin:H  antiporter (Ma et al., 2000))

Accession Number:Q9LA76
Protein Name:Valanimycin resistance
Length:402
Molecular Weight:41010.00
Species:Streptomyces viridifaciens [48665]
Number of TMSs:12
Substrate Valanimycin, protons

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (4)

[1] “A novel valanimycin-resistance determinant (vlmF) from Streptomyces viridifaciens MG456-hF10.”  Ma Y.et.al.   10708373
[2] “Cloning, analysis, and overexpression of the gene encoding isobutylamine N-hydroxylase from the valanimycin producer, Streptomyces viridifaciens.”  Parry R.J.et.al.   8990292
[3] “Purification and characterization of isobutylamine N-hydroxylase from the valanimycin producer Streptomyces viridifaciens MG456-hF10.”  Parry R.J.et.al.   9056232
[4] “Molecular characterization and analysis of the biosynthetic gene cluster for the azoxy antibiotic valanimycin.”  Garg R.P.et.al.   12406225

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTTEPLAAPV SPKTATGSPA RFWATAYTLL FLLTGTNLPT PLYRGYEHKF GFSPLVVTLI 
61:	FAVYVASLIP SLLIAGPLSD SIGRRKVLLP AVLLAAVGSL VFALADNVGW LFVARLLQGL 
121:	AVGAASGALT AALSELEPSG DRRRAALVST VASVGGLGAG PLIAGLLAEY APSPYVLPFV 
181:	VEIVLLVPAA IAMATLPTSR PATKWRPRRP SIPATMRGVF VSSGTASFLA FSVIGLFLSL 
241:	VPTYVTKLSG SSNLALAGGA VALMLACSVI AQIAASGRQP LAIQITGLVL LAVGLVLLAV 
301:	AGGVGSLALL LAATVIGGVG QGLAFLGGIT EINRVAPKER HADVLSSFYV VIYLGVGVPV 
361:	IGVGFLATVT GLLTAVQLFA AVVAALCLLD TLALARKRRE LT