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2.A.1.8.8
NO2- extrusion, NO3-/NO2- exchange permease, NarK1

Accession Number:Q9RA46
Protein Name:NarK1
Length:435
Molecular Weight:48218.00
Species:Thermus thermophilus [274]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate nitrate, Nitrite

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0055085 P:transmembrane transport

References (4)

[1] “Two nitrate/nitrite transporters are encoded within the mobilizable plasmid for nitrate respiration of Thermus thermophilus HB8.”  Ramirez S.et.al.   10735860
[2] “Development of a gene expression vector for Thermus thermophilus based on the promoter of the respiratory nitrate reductase.”  Moreno R.et.al.   12583995
[3] “A thermophilic nitrate reductase is responsible for the strain specific anaerobic growth of Thermus thermophilus HB8.”  Ramirez-Arcos S.et.al.   9540837
[4] “A cytochrome c encoded by the nar operon is required for the synthesis of active respiratory nitrate reductase in Thermus thermophilus.”  Zafra O.et.al.   12123812

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIHDPAQLEK ERPDRLRVLW LSTLAFTLMF AAWLMFGVLG VPIRKEFGLS DVQLSWISAL 
61:	AILNGSLWRL LAGILADRYG GRLVFTLMLF FTAIPAYLVS RAGSYEELLL YAFLVGFAGN 
121:	SFSVGIAWNS AWFPKDQQGF ALGVFGAGNV GASVTKFIGP ALIASVPASG YLGGLIPGGW 
181:	RFIPFLYAVL LVLMGFVLWF GTPRKDKRPG QGRPFLDMLK PLRYVRVWRF SLYYVVVFGA 
241:	YVALSAWLPK YYVDVFGLPL HEAALLTALF IFPASLLRPV GGYLSDRFGA RRIMYWTFGI 
301:	ILLASGVLMM PEGHIVLYTK QGAKEVMQFT MGVELFTLLV FLIGVGMGIG KAAVYKHIPT 
361:	YFPQDVGAVG GLVGMLGALG GFFLPPLFAY AQAWTGLPQM TFFVLFLLAA ISFLWMHLTV 
421:	LKLLQQEAQH LKKRL