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2.A.1.8.9
NO2- extrusion, NO3-/NO2- exchange permease, NarK2

Accession Number:Q9RA45
Protein Name:NarK2
Length:443
Molecular Weight:48843.00
Species:Thermus thermophilus [274]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Nitrite, nitrate

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015103 F:inorganic anion transmembrane transporter a...
GO:0015698 P:inorganic anion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Two nitrate/nitrite transporters are encoded within the mobilizable plasmid for nitrate respiration of Thermus thermophilus HB8.”  Ramirez S.et.al.   10735860
[2] “Development of a gene expression vector for Thermus thermophilus based on the promoter of the respiratory nitrate reductase.”  Moreno R.et.al.   12583995
[3] “A thermophilic nitrate reductase is responsible for the strain specific anaerobic growth of Thermus thermophilus HB8.”  Ramirez-Arcos S.et.al.   9540837
[4] “A cytochrome c encoded by the nar operon is required for the synthesis of active respiratory nitrate reductase in Thermus thermophilus.”  Zafra O.et.al.   12123812

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKSAKGTWI TDWNPEDPKR WDPALAWRTL WITTFNLTLS FITWYVVSAL VVRLPKVGFE 
61:	LSTTQLFWLT AMPGLAGGTL RIIWTFLPPI LGTRHLVTFS TLLLLIPLLG WGFAVQNTGT 
121:	PYWVLLLLAF LAGIGGGHFS GYMPSTSYFF PKRLQGTALG LQAGIGNFGV SIVQFVTPWI 
181:	IGFALFGSLL GGPQTFTPKP GVVPAHLAPE RHLRLGALVL LGALLAWVYL KSVPIRANFR 
241:	EQFDIFRDNH TWIMTTLYII TFGSFSGFSA IFPLLIREVY GKFEGAPDPL RYAFLGPLVG 
301:	SLARVIAGAI SDRLGGAIVT QVSAIGIFLS ALLVTLYTRP TSLDQFPMFV VAMLLIFFFS 
361:	GVGNASTFKQ MPMIFPPRQA GGVIGWTAAV AAYGPFLFST LAAYTQQATG GFTAFFYGLM 
421:	VFYAFNFFLN WYYYARKGAE KPC