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2.A.1.82.3
Synaptic vesicle 2-related protein (SV2-related protein), SVOP.  This protein localizes to neurotransmitter-containing vesicles and has a nucleotide binding site (Yao and Bajjalieh 2009). ATP, GTP and NAD show binding affinities with the highest affinity for NAD, in contrast to SV2 (TC# 2.A.1.22.1), which binds both NAD and ATP with equal affinity.

Accession Number:Q8BFT9
Protein Name:Synaptic vesicle 2-related protein
Length:548
Molecular Weight:60769.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate ATP, GTP, NAD

Cross database links:

Genevestigator: Q8BFT9
eggNOG: COG0477
HEGENOM: HOG000114543
Entrez Gene ID: 68666   
Pfam: PF07690    PF00083   
KEGG: mmu:68666   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0008021 C:synaptic vesicle
GO:0030672 C:synaptic vesicle membrane
GO:0015075 F:ion transmembrane transporter activity

References (4)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Proteomic analysis of in vivo phosphorylated synaptic proteins.”  Collins M.O.et.al.   15572359
[4] “Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.”  Munton R.P.et.al.   17114649

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDIQIEG VRVGLEAIEL DDGAAVPKEF 
61:	ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW 
121:	QVALLTSVVF IGMMSSSTLW GNISDQYGRK TGLKISVLWT LYYGILSAFA PVYSWILVLR 
181:	GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL 
241:	LLLSAAPLLL FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE 
301:	DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI SSRKKAVEAK 
361:	CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK KTMALCFIIF SLCSLLLFIC 
421:	IGRNVLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ 
481:	VMLESSVYLT LAVYSGCCLL AGVASCFLPI ETKGRALQES SHREWGQEMV GRGTNSAGVP 
541:	RSDSGSQE