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2.A.1.9.9
Inorganic phosphate transporter 1-1 (AtPht1;1; APT2, PHT1) (H+/Pi cotransporter).  A Brassica napus homologue, Pht1;4, catalyzes phosphate uptake and affects root architecture (Ren et al. 2014). The phylogeny and expression levels in plant tissues of the proteins of this family in potato have been examined (Liu et al. 2017).

Accession Number:Q8VYM2
Protein Name:Inorganic phosphate transporter 1-1
Length:524
Molecular Weight:57616.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate phosphate

Cross database links:

Genevestigator: Q8VYM2
eggNOG: COG0477
HEGENOM: HOG000171120
Entrez Gene ID: 834353   
Pfam: PF00083   
KEGG: ath:AT5G43350   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005315 F:inorganic phosphate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0016036 P:cellular response to phosphate starvation

References (12)

[1] “Phosphate transporters from the higher plant Arabidopsis thaliana.”  Muchhal U.S.et.al.   8927627
[2] “The cloning of two Arabidopsis genes belonging to a phosphate transporter family.”  Smith F.W.et.al.   9025304
[3] “Overexpression of an Arabidopsis thaliana high-affinity phosphate transporter gene in tobacco cultured cells enhances cell growth under phosphate-limited conditions.”  Mitsukawa N.et.al.   9192698
[4] “Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10718197
[5] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[6] “Expression analysis suggests novel roles for members of the Pht1 family of phosphate transporters in Arabidopsis.”  Mudge S.R.et.al.   12164813
[7] “Phosphite, an analog of phosphate, suppresses the coordinated expression of genes under phosphate starvation.”  Varadarajan D.K.et.al.   12114577
[8] “Regulated expression of Arabidopsis phosphate transporters.”  Karthikeyan A.S.et.al.   12226502
[9] “Phosphate transport in Arabidopsis: Pht1;1 and Pht1;4 play a major role in phosphate acquisition from both low- and high-phosphate environments.”  Shin H.et.al.   15272879
[10] “Promoter of Arabidopsis thaliana phosphate transporter gene drives root-specific expression of transgene in rice.”  Koyama T.et.al.   16233751
[11] “PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 is a plant-specific SEC12-related protein that enables the endoplasmic reticulum exit of a high-affinity phosphate transporter in Arabidopsis.”  Gonzalez E.et.al.   16284308
[12] “Novel subsets of the Arabidopsis plasmalemma phosphoproteome identify phosphorylation sites in secondary active transporters.”  Hem S.et.al.   17869214

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEQQLGVLK ALDVAKTQLY HFTAIVIAGM GFFTDAYDLF CVSLVTKLLG RIYYFNPESA 
61:	KPGSLPPHVA AAVNGVALCG TLSGQLFFGW LGDKLGRKKV YGLTLVMMIL CSVASGLSFG 
121:	HEAKGVMTTL CFFRFWLGFG IGGDYPLSAT IMSEYANKKT RGAFIAAVFA MQGVGILAGG 
181:	FVALAVSSIF DKKFPAPTYA VNRALSTPPQ VDYIWRIIVM FGALPAALTY YWRMKMPETA 
241:	RYTALVAKNI KQATADMSKV LQTDIELEER VEDDVKDPKQ NYGLFSKEFL RRHGLHLLGT 
301:	TSTWFLLDIA FYSQNLFQKD IFSAIGWIPK AATMNATHEV FRIARAQTLI ALCSTVPGYW 
361:	FTVAFIDTIG RFKIQLNGFF MMTVFMFAIA FPYNHWIKPE NRIGFVVMYS LTFFFANFGP 
421:	NATTFIVPAE IFPARLRSTC HGISAAAGKA GAIVGAFGFL YAAQSQDKAK VDAGYPPGIG 
481:	VKNSLIMLGV LNFIGMLFTF LVPEPKGKSL EELSGEAEVS HDEK