2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KDGT) Family

The KdgT permease of Erwinia chrysanthemi is the only well-characterized member of the KDGT family although homologues are present in E. coli and Bacillus subtilis. Thus, members of the family are present both in Gram-negative and Gram-positive bacteria. The protein from E. chrysanthemi possesses 398 amino acids and probably traverses the membrane as α-helicies 10-12 times. Uptake is energized by proton symport.

The transport reaction catalyzed by KdgT is:

KDG (out) + H+ (out) ⇌ KDG (in) + H+ (in).