2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family
The KdgT permease of Erwinia chrysanthemi is the only well-characterized member of the KdgT family although homologues are present in many bacteria. Thus, members of the family are present both in Gram-negative and Gram-positive bacteria (Allen et al. 1989). The protein from E. chrysanthemi possesses 398 amino acids and probably traverses the membrane as α-helicies 10-12 times. Uptake is energized by proton symport (Condemine and Robert-Baudouy 1987).
The transport reaction catalyzed by KdgT is:
KDG (out) + H+ (out) ⇌ KDG (in) + H+ (in).