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2.A.100.1.1
The iron exporter Ferroportin1 (Fnp1 or IREG1)

Accession Number:Q9JHI9
Protein Name:IREG1 aka SLC40A1 aka FPN1 aka SLC39A1
Length:570
Molecular Weight:62702.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate iron

Cross database links:

Genevestigator: Q9JHI9
HEGENOM: HBG444501
RefSeq: NP_058613.2   
Entrez Gene ID: 53945   
KEGG: mmu:53945   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008021 C:synaptic vesicle
GO:0005381 F:iron ion transmembrane transporter activity
GO:0006826 P:iron ion transport

References (5)

[1] “A novel mammalian iron-regulated protein involved in intracellular iron metabolism.”  Abboud S.et.al.   10747949
[2] “Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.”  Donovan A.et.al.   10693807
[3] “A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.”  McKie A.T.et.al.   10882071
[4] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL 
61:	TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKNEL 
121:	LTMYHGWVLT VCYILIITIA NIANLASTAT AITIQRDWIV VVAGENRSRL ADMNATIRRI 
181:	DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK 
241:	VEESELKQLT SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV 
301:	SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF 
361:	TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFVNVEPVSP 
421:	TTKIPETVFT TEMHMSNMSN VHEMSTKPIP IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ 
481:	ENVIESERGI INGVQNSMNY LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF 
541:	AQKTLGNQIF VCGPDEKEVT DENQPNTSVV