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2.A.100.1.4
Solute carrier family 40 member 1 (Ferroportin-1; FPN1) (Iron-regulated transporter 1).  Transports iron, cobalt, zinc and manganese and maybe copper (Madejczyk and Ballatori 2012).  Regulated by its inhibitor, the processed liver antimicrobial peptide, hepcidin (TC# 8.A.37.1.2).  Tryptophan 42, a hemochromatosis type 4 disease residue, plays a role in iron export and iron homeostasis as well as hepcidin binding (Le Gac et al. 2013).  This protein has been modeled using the MSF EmrD of E. coli (TC# 2.A.1.2.9) (Le Gac et al. 2013). Defects can be corrected by adding the small molecule, hinokitiol (Cioffi et al. 2015; Grillo et al. 2017).

Accession Number:Q9NP59
Protein Name:Solute carrier family 40 member 1
Length:571
Molecular Weight:62542.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Fe2+, Mn2+, Co2+, Zn2+, Cu2+

Cross database links:

Genevestigator: Q9NP59
eggNOG: NOG273752
HEGENOM: HOG000234273
Entrez Gene ID: 30061   
Pfam: PF06963   
KEGG: hsa:30061   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0005887 C:integral to plasma membrane
GO:0008021 C:synaptic vesicle
GO:0005381 F:iron ion transmembrane transporter activity
GO:0009653 P:anatomical structure morphogenesis
GO:0006915 P:apoptotic process
GO:0006879 P:cellular iron ion homeostasis
GO:0003158 P:endothelium development
GO:0002260 P:lymphocyte homeostasis
GO:0060586 P:multicellular organismal iron ion homeostasis
GO:0060345 P:spleen trabecula formation

References (21)

[1] “A novel mammalian iron-regulated protein involved in intracellular iron metabolism.”  Abboud S.et.al.   10747949
[2] “A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.”  McKie A.T.et.al.   10882071
[3] “Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.”  Donovan A.et.al.   10693807
[4] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload.”  Zaahl M.G.et.al.   15338274
[7] “Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.”  Yu L.-R.et.al.   17924679
[8] “Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.”  Montosi G.et.al.   11518736
[9] “A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis.”  Njajou O.T.et.al.   11431687
[10] “Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis.”  Wallace D.F.et.al.   12091366
[11] “Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).”  Devalia V.et.al.   12091367
[12] “A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4.”  Roetto A.et.al.   12123233
[13] “Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3).”  Cazzola M.et.al.   12406098
[14] “Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (SLC11A3) mutations.”  Hetet G.et.al.   12730114
[15] “Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene.”  Gordeuk V.R.et.al.   14636642
[16] “A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient.”  Arden K.E.et.al.   12865285
[17] “Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family.”  Rivard S.R.et.al.   12857562
[18] “Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload.”  Jouanolle A.-M.et.al.   12873829
[19] “The ferroportin disease.”  Pietrangelo A.et.al.   14757427
[20] “Recent advances in understanding haemochromatosis: a transition state.”  Robson K.J.H.et.al.   15466004
[21] “Genetic and clinical heterogeneity of ferroportin disease.”  Cremonesi L.et.al.   16351644

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTRAGDHNRQ RGCCGSLADY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL 
61:	TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKHEL 
121:	LTMYHGWVLT SCYILIITIA NIANLASTAT AITIQRDWIV VVAGEDRSKL ANMNATIRRI 
181:	DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY VLLWKVYQKT PALAVKAGLK 
241:	EEETELKQLN LHKDTEPKPL EGTHLMGVKD SNIHELEHEQ EPTCASQMAE PFRTFRDGWV 
301:	SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF 
361:	TWLRRKCGLV RTGLISGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFIQGESITP 
421:	TKIPEITTEI YMSNGSNSAN IVPETSPESV PIISVSLLFA GVIAARIGLW SFDLTVTQLL 
481:	QENVIESERG IINGVQNSMN YLLDLLHFIM VILAPNPEAF GLLVLISVSF VAMGHIMYFR 
541:	FAQNTLGNKL FACGPDAKEV RKENQANTSV V