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2.A.103.1.1
Cell division protein, FtsW.  May flip lipid II (involved in cell wall synthesis) across the cytoplasmic membrane.  R145 and K153 in TMS 4 (of 10) are esesential for this transport activity (Mohammadi et al. 2014).  There is some controversy about this transport function (Young 2014; Sham et al. 2014).  See TC#2.A.66.4.3 for the alternative explanation.

Accession Number:P0ABG4
Protein Name:Cell division protein FtsW aka B0089
Length:414
Molecular Weight:45987.00
Species:Escherichia coli [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Lipid II

Cross database links:

Genevestigator: P0ABG4 P0ABG4
EchoBASE: EB0340 EB0340
EcoGene: EG10344 EG10344
eggNOG: COG0772 COG0772
HEGENOM: HBG729614 HBG729614
DIP: DIP-47989N DIP-47989N
RefSeq: AP_000752.1    NP_414631.1   
Entrez Gene ID: 946322   
Pfam: PF01098   
BioCyc: EcoCyc:EG10344-MONOMER    ECOL168927:B0089-MONOMER   
KEGG: ecj:JW0087    eco:b0089    ecj:JW0087    eco:b0089   

Gene Ontology

GO:0032155 C:cell division site part
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0007049 P:cell cycle
GO:0007047 P:cellular cell wall organization
GO:0000910 P:cytokinesis
GO:0009252 P:peptidoglycan biosynthetic process
GO:0008360 P:regulation of cell shape

References (18)

[1] “Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.”  Ikeda M.et.al.   2509435
[2] “Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.”  Yura T.et.al.   1630901
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Nucleotide sequence involving murG and murC in the mra gene cluster region of Escherichia coli.”  Ikeda M.et.al.   2197603
[6] “ftsW is an essential cell-division gene in Escherichia coli.”  Boyle D.S.et.al.   9218774
[7] “Identification of FtsW and characterization of a new ftsW division mutant of Escherichia coli.”  Khattar M.M.et.al.   7961485
[8] “Two polypeptide products of the Escherichia coli cell division gene ftsW and a possible role for FtsW in FtsZ function.”  Khattar M.M.et.al.   9006034
[9] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[10] “Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.”  Ikeda M.et.al.   2509435
[11] “Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.”  Yura T.et.al.   1630901
[12] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[13] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[14] “Nucleotide sequence involving murG and murC in the mra gene cluster region of Escherichia coli.”  Ikeda M.et.al.   2197603
[15] “ftsW is an essential cell-division gene in Escherichia coli.”  Boyle D.S.et.al.   9218774
[16] “Identification of FtsW and characterization of a new ftsW division mutant of Escherichia coli.”  Khattar M.M.et.al.   7961485
[17] “Two polypeptide products of the Escherichia coli cell division gene ftsW and a possible role for FtsW in FtsZ function.”  Khattar M.M.et.al.   9006034
[18] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRLSLPRLKM PRLPGFSILV WISTALKGWV MGSREKDTDS LIMYDRTLLW LTFGLAAIGF 
61:	IMVTSASMPI GQRLTNDPFF FAKRDGVYLI LAFILAIITL RLPMEFWQRY SATMLLGSII 
121:	LLMIVLVVGS SVKGASRWID LGLLRIQPAE LTKLSLFCYI ANYLVRKGDE VRNNLRGFLK 
181:	PMGVILVLAV LLLAQPDLGT VVVLFVTTLA MLFLAGAKLW QFIAIIGMGI SAVVLLILAE 
241:	PYRIRRVTAF WNPWEDPFGS GYQLTQSLMA FGRGELWGQG LGNSVQKLEY LPEAHTDFIF 
301:	AIIGEELGYV GVVLALLMVF FVAFRAMSIG RKALEIDHRF SGFLACSIGI WFSFQALVNV 
361:	GAAAGMLPTK GLTLPLISYG GSSLLIMSTA IMMLLRIDYE TRLEKAQAFV RGSR