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2.A.103.1.2
Rod shape determining protein, RodA.  A proposed flippase for a lipid-linked disaccharide-pentapeptide cell wall precursor, but this proposal is controversial (Sham et al. 2014; Young 2014).

Accession Number:P0ABG7
Protein Name:RodA aka MRDB aka B0634
Length:370
Molecular Weight:40476.00
Species:Escherichia coli [83333]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Lipid II

Cross database links:

Genevestigator: P0ABG7 P0ABG7
EchoBASE: EB0602 EB0602
EcoGene: EG10607 EG10607
eggNOG: COG0772 COG0772
HEGENOM: HBG729614 HBG729614
DIP: DIP-48062N DIP-48062N
RefSeq: AP_001283.1    NP_415167.1   
Entrez Gene ID: 945238   
Pfam: PF01098   
BioCyc: EcoCyc:EG10607-MONOMER    ECOL168927:B0634-MONOMER   
KEGG: ecj:JW0629    eco:b0634    ecj:JW0629    eco:b0634   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0007049 P:cell cycle
GO:0008360 P:regulation of cell shape

References (12)

[1] “Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon.”  Matsuzawa H.et.al.   2644207
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Genes encoding two lipoproteins in the leuS-dacA region of the Escherichia coli chromosome.”  Takase I.et.al.   3316191
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[7] “Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon.”  Matsuzawa H.et.al.   2644207
[8] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[9] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[10] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[11] “Genes encoding two lipoproteins in the leuS-dacA region of the Escherichia coli chromosome.”  Takase I.et.al.   3316191
[12] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MTDNPNKKTF WDKVHLDPTM LLILLALLVY SALVIWSASG QDIGMMERKI GQIAMGLVIM 
61:	VVMAQIPPRV YEGWAPYLYI ICIILLVAVD AFGAISKGAQ RWLDLGIVRF QPSEIAKIAV 
121:	PLMVARFINR DVCPPSLKNT GIALVLIFMP TLLVAAQPDL GTSILVALSG LFVLFLSGLS 
181:	WRLIGVAVVL VAAFIPILWF FLMHDYQRQR VMMLLDPESD PLGAGYHIIQ SKIAIGSGGL 
241:	RGKGWLHGTQ SQLEFLPERH TDFIFAVLAE ELGLVGILIL LALYILLIMR GLWIAARAQT 
301:	TFGRVMAGGL MLILFVYVFV NIGMVSGILP VVGVPLPLVS YGGSALIVLM AGFGIVMSIH 
361:	THRKMLSKSV