TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.106.1.1









The Y615 protein
Bacteria
Cyanobacteria
Y615 of Synechocystis PCC6803
2.A.106.1.2









Uncharacterized protein of 194 aas and 6 TMSs with two 3-TMS repeats.

Bacteria
Actinobacteria
UP of Streptomyces griseus
2.A.106.1.3









Uncharacterized protein of 213 aas and 6 TMSs

Bacteria
Bacteroidetes/Chlorobi group
UP of Chlorobium chlorochromatii
2.A.106.1.4









Uncharacterized protein of 192 aas

Bacteria
Proteobacteria
UP of Acidovorax ebreus
2.A.106.1.5









Chloroplast thylakoid GDT-1-like protein or photosynthesis-affected protein-71, PAM71 of 370 aas. Takes up Mn2+ and influences both Mn2+ and Ca2+ homeostasis in the chloroplast.  Necessary for photosystem II function due to its Mn2+ uptake activity (Schneider et al. 2016; Hoecker et al. 2017).

Eukaryota
Viridiplantae
PAM71 of Arabidopsis thaliana
2.A.106.1.6









Manganese (Mn2+):proton exchanger, CGLD1, of 340 aas (Schneider et al. 2016; ).

Eukaryota
Viridiplantae
CGLD1 of Chlamydomonas reinhardtii (Chlamydomonas smithii)
2.A.106.1.7









Photosynthesis-affected mutant 71, PAM71 homologue, PAM71-HL, of 359 aas and 7 TMSs (Hoecker et al. 2017). Probably a manganese ion transporter; a member of the UPF0016 family.

Eukaryota
Viridiplantae
PAM71-HL of Arabidopsis thaliana (Mouse-ear cress)
2.A.106.1.8









Putative DL-lactate uptake porter of 184 aas and 6 - 7 TMSs (Deutschbauer et al. 2011).

Bacteria
Proteobacteria
SO_1071 of Shewanella oneidensis
2.A.106.2.1









The PFT27 protein
Eukaryota
Metazoa
PFT27 of Mus musculus
2.A.106.2.2









Ca2+:H+ antiporter, TMEM165 (PT27; TPARL) of 324 aas and 7 TMSs in a 1 (N-terminal) + 3 + 3 TMS arrangement (Demaegd et al. 2013).  It may be both a Ca2+:H+ and a Mn2+:H+ antiporter (Dulary et al. 2016), catalyzing uptake of Mn2+ from the cytoplasm into the golgi lumen.  TMEM165 has been linked to congenital disorders of glycosylation (CDG) (Foulquier et al. 2012). It may influence glycosylation due to its Mn2+ transport activity that regulates Mn2+ homeostasis in the golgi (Thines et al. 2018). TMEM165 is also required for milk production (Snyder et al. 2019). Human Both Ca2+ and Mn2+ are required for proper protein glycosylation in cells (Stribny et al. 2020). TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma, and its depletion impairs invasion activity (Lee et al. 2018).

Eukaryota
Metazoa
TMEM165 of Homo sapiens (Q9HC07)
2.A.106.2.3









Golgi Ca2+:H+ and Mn2+:H+ antiporter, Gdt1 (GCR-1-dependent translation factor 1) or TMEM165 (Demaegd et al., 2013).  Involved in ion homeostasis (Dulary et al. 2016), specifically Mn2+ homeostasis (Thines et al. 2018).

Eukaryota
Fungi
Gdt1 of Saccharomyces cerevisiae (P38301)
2.A.106.2.4









The YD68 protein
Eukaryota
Fungi
YD68 of Schizosaccharomyces pombe
2.A.106.2.5









Golgi Ca2+ ion homeostasis protein, TM protein PFT27, of 515 aas and 8 putative TMSs in a 2 (N-terminal) + 3 (middle) + 3 (C-terminal) TMSs.

Eukaryota
Fungi
Transmembrane protein PFT27 of Pyrenophora tritici-repentis (Wheat tan spot fungus) (Drechslera tritici-repentis)
2.A.106.3.1









3 TMS homologue of 89 aas

Bacteria
Spirochaetes
3 TMS homologue of Leptonema illini
2.A.106.3.2









3 TMS homologue of 90 aas

Bacteria
Proteobacteria
3 TMS homologue of Bdellovibrio bacteriovorus
2.A.106.4.1









Uncharacterized protein of 235 aas

Archaea
Euryarchaeota
UP of Haloarcula japonica