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2.A.106.2.2
Ca2+:H+ antiporter, TMEM165 (PT27; TPARL) of 324 aas and 7 TMSs in a 1 (N-terminal) + 3 + 3 TMS arrangement (Demaegd et al. 2013).  It may be both a Ca2+:H+ and a Mn2+:H+ antiporter (Dulary et al. 2016), catalyzing uptake of Mn2+ from the cytoplasm into the golgi lumen.  TMEM165 has been linked to congenital disorders of glycosylation (CDG) (Foulquier et al. 2012). It may influence glycosylation due to its Mn2+ transport activity that regulates Mn2+ homeostasis in the golgi (Thines et al. 2018). TMEM165 is also required for milk production (Snyder et al. 2019). Human Both Ca2+ and Mn2+ are required for proper protein glycosylation in cells (Stribny et al. 2020). TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma, and its depletion impairs invasion activity (Lee et al. 2018).

Accession Number:Q9HC07
Protein Name:Transmembrane protein 165
Length:324
Molecular Weight:34906.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, protons

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FASTA formatted sequence
1:	MAAAAPGNGR ASAPRLLLLF LVPLLWAPAA VRAGPDEDLS HRNKEPPAPA QQLQPQPVAV 
61:	QGPEPARVEK IFTPAAPVHT NKEDPATQTN LGFIHAFVAA ISVIIVSELG DKTFFIAAIM 
121:	AMRYNRLTVL AGAMLALGLM TCLSVLFGYA TTVIPRVYTY YVSTVLFAIF GIRMLREGLK 
181:	MSPDEGQEEL EEVQAELKKK DEEFQRTKLL NGPGDVETGT SITVPQKKWL HFISPIFVQA 
241:	LTLTFLAEWG DRSQLTTIVL AAREDPYGVA VGGTVGHCLC TGLAVIGGRM IAQKISVRTV 
301:	TIIGGIVFLA FAFSALFISP DSGF