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2.A.108.2.1
The lead (Pb2+) uptake porter, PbrT

Accession Number:Q58AJ4
Protein Name:PbrT
Length:642
Molecular Weight:68264.00
Species:Ralstonia metallidurans (strain CH34) [266264]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Lead 2+

Cross database links:

eggNOG: COG0672
HEGENOM: HBG400287
RefSeq: YP_145618.1    YP_145621.1    YP_145624.1    YP_581754.1    YP_581757.1    YP_581760.1   
Entrez Gene ID: 3170370    3170446    4036383    4036386    7564719   
Pfam: PF00034    PF03239   
BioCyc: RMET266264:RMET_5945-MONOMER   
KEGG: rme:Rmet_5945   

Gene Ontology

GO:0016020 C:membrane
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0055085 P:transmembrane transport

References (2)

[1] “The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to the removal of heavy metals.”  Diels L.et.al.   7766206
[2] “Cloning and functional analysis of the pbr lead resistance determinant of Ralstonia metallidurans CH34.”  Borremans B.et.al.   11544228

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MQALRLLSIV LLSLFVTVST AQADPLATQD KAKQIWQVLD YLAVDYGRSV KDGHVANEAE 
61:	YAEMQEFAQA AERQLTELPP TPAAPELAKE AAALRASIAE KAPPESVGEQ ARKLAGGLLA 
121:	AYPVPMAPGK LPDLQQGAKL YQSQCASCHG VSGHADGPLA AKLSPPPIAL ADHERAQERS 
181:	VFALQQIITR GVEGTSMPAF AQLSDEERWA LAYFASTLSY SDADRQAGAK LWTSQPALHA 
241:	AVPTLALLSQ TSEAALAKTV GADAARQLTA YLRSTPGSVT ASSTDSLMIA RDKLKESLAT 
301:	LDKGDRQLAS RLALSAYLDG FEPVEPALAA KNQALFQDIE KTMGLYRNAV TAGQVERAHE 
361:	IAQKLQSQLD DAQEALGGTN DAISTFLGAL TILLREGLEA LLVVVAMMAF LKKADRTDVL 
421:	PYVHAGWVTA LAAGGLTWAV ATYVVDLSGA SREMTEGFSA VFAAIVLLGV GMWMHQKSLA 
481:	GRWQAYVKAK LSSALNKKSA LMLFLLSFVT VYREVFETVL FYAALWTEGN GVFLLAGLAS 
541:	GIAILAAIAI VLLRSTARLP IGQFFAFSSA LVGVLAVVLI GKGIAALQKV GFLQVTPISM 
601:	PRIDVLGIYP SVQTVVAQVL ILLIIAASVV YNLRSHRPST QV